SENP8
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Official Full Name
SUMO/sentrin specific peptidase family member 8 -
Overview
This gene encodes a cysteine protease that is a member of the sentrin-specific protease family. The encoded protein is involved in processing and deconjugation of the ubiquitin-like protein termed, neural precursor cell expressed developmentally downregulated 8. Alternate splicing results in multiple transcript variants. -
Synonyms
SENP8;SUMO/sentrin specific peptidase family member 8;protease, cysteine, 2 (NEDD8 specific) , PRSC2, SUMO/sentrin specific protease family member 8;sentrin-specific protease 8;DEN1;deneddylase 1;HsT17512;NEDD8 specific protease 1;NEDP1;sentrin/
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Zebrafish
- Rat
- Chicken
- E.coli
- Mammalian Cell
- HEK293
- E. coli
- HEK293T
- His
- GST
- Non
- His&Fc&Avi
- His&SUMO
- Myc&DDK
Involved Pathway
SENP8 involved in several pathways and played different roles in them. We selected most pathways SENP8 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SENP8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
SENP8 has several biochemical functions, for example, cysteine-type peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SENP8 itself. We selected most functions SENP8 had, and list some proteins which have the same functions with SENP8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cysteine-type peptidase activity | BLMH,SOLH,USP12A,DESI2,USP17L1P,GM12824,USP9,OTUD4,SENP3A,CAPN2A |
Interacting Protein
SENP8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SENP8 here. Most of them are supplied by our site. Hope this information will be useful for your research of SENP8.
RPL11;NEDD8
Resources
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References
- Curtis, VF; Ehrentraut, SF; et al. Stabilization of HIF through inhibition of Cullin-2 neddylation is protective in mucosal inflammatory responses. FASEB JOURNAL 29:208-215(2015).
- Curtis, V; Ehrentraut, S; et al. Contribution of human deneddylase-1/SENP8 to the mucosal inflammatory response. FASEB JOURNAL 28:-(2014).
