SEC61B
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Official Full Name
Sec61 beta subunit -
Overview
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that these proteins can escape the ER and recycle back. There is evidence for multiple polyadenylated sites for this transcript. -
Synonyms
SEC61B;Sec61 beta subunit;protein transport protein Sec61 subunit beta;Protein translocation complex beta;Protein transport protein SEC61 beta subunit;SEC 61B;SEC61 B;Sec61 complex beta subunit;Sec61 complex, beta subunit
Recombinant Proteins
- Human
- Rhesus macaque
- Chicken
- Zebrafish
- Dog
- E.coli
- Mammalian Cells
- HEK293
- His
- Non
- Avi
- Fc
Involved Pathway
SEC61B involved in several pathways and played different roles in them. We selected most pathways SEC61B participated on our site, such as Adaptive Immune System,Antigen processing-Cross presentation,Class I MHC mediated antigen processing &, which may be useful for your reference. Also, other proteins which involved in the same pathway with SEC61B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Antigen processing-Cross presentation | CYBA,CTSL2,CTSS,CTSL1,FCGR1B,CYBB,CD207 |
| Immune System | TREML1,AP1B1,MGC174152,RCA2.1,RNF144B,HUWE1,XAF1,TXNIP,IFIT12,TRIM10 |
| Gene Expression | CPSF4,DNMT3L,ZNF254,HNRNPH1,MYBL1,PAPOLA,LCMT2,SNAPC5,NRBP1,COX6A1 |
| presentation | BLMH,ASB13,TRIM11,TRIM39,LRSAM1,ASB14,RNF144B,CTSS,TRIM9,KLHL21 |
| IRE1alpha activates chaperones | SERP1,HYOU1,FKBP14,WIPI1,KDELR3,ASNA1,SEC63,CTDSP2,PDIA6,CXXC1 |
| Metabolism of proteins | MUC5AC,MPDU1,MPDU1B,TIMM21,TBCA,ST8SIA3,DPH5,CNIH3,SEC63,TIMM17A |
| Adaptive Immune System | LILRB1,SIGLEC10,ACTR1B,LAIR2,PAG1,CD300LH,SPSB4,Mill2,TRIM69,TREML2 |
| Class I MHC mediated antigen processing & | PJA1,RNF14,ERAP1,FCGR1B,PJA2,RNF123,UBE2V2,RNF41,RBCK1,LRSAM1 |
Protein Function
SEC61B has several biochemical functions, for example, epidermal growth factor binding,poly(A) RNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SEC61B itself. We selected most functions SEC61B had, and list some proteins which have the same functions with SEC61B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | PRPF38B,DEK,NOL11,ZFP36L1,DIMT1L,GNL2,EIF4H,FBL,MCAT,MRPL40 |
| protein binding | MAPK7,RPAP3,LAMP2,EDDM3B,AKT1,RBMS1,MET,NPC1,ARHGAP4,GDPD5 |
| ribosome binding | HSPA5,CPEB1A,RICTOR,ETF1B,CPEB1,EIF2S1,IGHMBP2,ETF1A,CPEB4,NARG1 |
Interacting Protein
SEC61B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SEC61B here. Most of them are supplied by our site. Hope this information will be useful for your research of SEC61B.
BCAP31;SSR1;AURKA;BUB1;MCC;BMPR1A;acpA;CDKN2A;FBXW7;ATP13A2;MLH3;MUTYH;ATG2A;Max
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References
- Choi, SY; Fogelgren, B; et al. Exocyst Sec10 Is Involved in Basolateral Protein Translation and Translocation in the Endoplasmic Reticulum. NEPHRON EXPERIMENTAL NEPHROLOGY 120:E133-E139(2012).
- Boisrame, A; Chasles, M; et al. Sbh1p, a subunit of the Sec61 translocon, interacts with the chaperone calnexin in the yeast Yarrowia lipolytica. JOURNAL OF CELL SCIENCE 115:4947-4956(2002).
