SAP18
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Official Full Name
Sin3A-associated protein, 18kDa -
Overview
Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. A pseudogene has been identified on chromosome 2. -
Synonyms
SAP18;Sin3A-associated protein, 18kDa;SAP18P;2HOR0202;histone deacetylase complex subunit SAP18;SIN3-associated protein p18;sin3-associated polypeptide p18;sin3-associated polypeptide, p18;cell growth inhibiting protein 38;MGC27131;cell growth-inhibiting protein 38;18 kDa Sin3-associated polypeptide;sin3-associated polypeptide, 18 kDa;cell growth-inhibiting gene 38 protein;histone deacetlyase complex subunit SAP18;OTTHUMP00000018107;OTTHUMP00000211540;SIN3-associated protein p18 (SAP 18)
Recombinant Proteins
- Zebrafish
- Mouse
- Human
- Rhesus macaque
- Chicken
- Mammalian Cell
- E.coli
- Human
- HEK293
- HEK293T
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
SAP18 involved in several pathways and played different roles in them. We selected most pathways SAP18 participated on our site, such as Chromatin modifying enzymes,Chromatin organization,Epigenetic regulation of gene expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with SAP18 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Epigenetic regulation of gene expression | MTF2,CD3EAP,DNMT3L,DNMT3B,DNMT3A,H3F3B.1,TAF1C,SUZ12B,TAF1A,SAP130 |
| Chromatin modifying enzymes | MORF4L2,KDM1B,ING5,EP400,EHMT2,DMAP1,SMARCC1B,BRPF1,SMARCB1B,SAP30 |
| Negative epigenetic regulation of rRNA expression | BAZ2A,TAF1D,DNMT1,SAP30L,SIN3B,TAF1C,SAP30,SAP130,SAP30BP,SUDS3 |
| Hedgehog signaling events mediated by Gli proteins | SPOP,CSNK1G3,SIN3B,LGALS3,KIF3A,MTSS1,CSNK1G2,SAP30,IFT88 |
| Gene Expression | TCEB3,MED8,ZNF559,TXN,ZNF738,SNAPC1B,IPO8,CTGF,ZNF394,ZKSCAN1 |
| HDACs deacetylate histones | MBD3B,PHF21A,SAP30L,ANO9A,GATAD2B,MTA1,CHD4,SUDS3,ARID4A,GATAD2A |
| Hedgehog signaling pathway | SHHB,WNT3,DYRK1A,WNT6,IHHB,ZIC2B,PRKACB,FBXW11A,FBXW11,WNT7AA |
| Chromatin organization | ASH2L,COPRS,KAT7B,BRPF1,KAT8,PADI4,DR1,SAP30L,PADI6,DNMT3A |
Protein Function
SAP18 has several biochemical functions, for example, poly(A) RNA binding,protein binding,transcription corepressor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SAP18 itself. We selected most functions SAP18 had, and list some proteins which have the same functions with SAP18. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription corepressor activity | HDAC3,TRIB3,PEX14,TBL1XR1,MSC,BATF3,HDAC4,SRSF2,ASXL1,SSX1 |
| poly(A) RNA binding | TDRD3,G3BP2,RPS13,LARP7,RPS20,MRPL32,SND1,TIA1,CS,MRPS24 |
| protein binding | PIK3CB,TOP3B,BFSP1,MUM1,NR1D2,MOBKL2B,CTTNBP2NL,ZNF263,STOML1,HCK |
Interacting Protein
SAP18 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SAP18 here. Most of them are supplied by our site. Hope this information will be useful for your research of SAP18.
RBM39;INCA1;RBM39;HDAC1;EIF4A3;13514813;RGS10;ATP5L;GLS
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