S1PR4
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Official Full Name
sphingosine-1-phosphate receptor 4 -
Overview
This gene is a member of the endothelial differentiation, G-protein-coupled (EDG)) receptor gene family. EDG receptors bind lysophospholipids or lysosphingolipids as ligands, and are involved in cell signalling in many different cell types. This EDG receptor gene is intronless and is specifically expressed in the lymphoid tissue. -
Synonyms
S1PR4;sphingosine-1-phosphate receptor 4;EDG6, endothelial differentiation, G protein coupled receptor 6 , endothelial differentiation, lysophosphatidic acid G protein coupled receptor, 6;sphingosine 1-phosphate receptor 4;Endothelial differentiationlysophosphatidic acid G protein coupled receptor 6;Endothelial differentiation G protein coupled receptor 6;Endothelial differentiation G-protein coupled receptor 6;Endothelial differentiation gene 6;LPC1;Lysophospholipid receptor C1;MGC129298;Putative G protein coupled receptor;S1P receptor 4;S1P receptor Edg-6;S1P receptor Edg6;S1P4;S1PR4_HUMAN;SLP4;Sphingosine 1 phosphate receptor 4;Sphingosine 1 phosphate receptor Edg6;Sphingosine 1-phosphate receptor Edg-6;endothelial differentiation, G protein coupled receptor 6;endothelial differentiation, G-protein-coupled receptor 6;endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 6;EDG6
Recombinant Proteins
- Mouse
- Human
- Rhesus macaque
- Zebrafish
- Mammalian Cell
- Wheat Germ
- HEK293
- E.coli expression system
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
Involved Pathway
S1PR4 involved in several pathways and played different roles in them. We selected most pathways S1PR4 participated on our site, such as FoxO signaling pathway,Sphingolipid signaling pathway,Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with S1PR4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neuroactive ligand-receptor interaction | RXFP2,CHRM2A,GPR156,GLRA2,TAAR14I,OPRD1A,CALCRL,PTGER1C,SCTR,GRID1 |
| FoxO signaling pathway | GABARAPL1,MAPK3,CDKN1BA,GABARAPA,HRAS,AKT1,IGF1R,PIK3CG,PRKAG3,FOXG1A |
| Sphingolipid signaling pathway | RAC3,MAPK13,RHOA,SGPL1,MAP2K2,SPTLC3,FCER1A,CERS4,TNFRSF1A,TRP53 |
Protein Function
S1PR4 has several biochemical functions, for example, G-protein coupled receptor activity,lipid binding,sphingosine-1-phosphate receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by S1PR4 itself. We selected most functions S1PR4 had, and list some proteins which have the same functions with S1PR4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| sphingosine-1-phosphate receptor activity | S1PR3,S1PR1,SPHK1,S1PR5B,S1PR3A,S1PR5,SPHK2,S1PR5A,GPR6,S1PR2 |
| G-protein coupled receptor activity | VMN1R54,RRH,PTGER1C,OR2F1,OR2B3,TPRA1,OR7D2,OR2C1,NTSR2,OR2AP1 |
| lipid binding | FFAR2,UNC119.1,CRABP2A,CPTP,UNC119,RBP2B,ACBD5,PITPNA,APOA4A,RBP7B |
Interacting Protein
S1PR4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with S1PR4 here. Most of them are supplied by our site. Hope this information will be useful for your research of S1PR4.
Resources
Research Area
Endothelial Cell Development MoleculesEndothelial Cell Markers
Endothelial Cell Differentiation Markers
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References
