RuvC
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Official Full Name
RuvC -
Overview
In Escherichia coli, the RuvA, RuvB and RuvC proteins are required for the late stages of homologous recombination and DNA repair. They are involved in processing the Holliday junction during homologous recombination. RuvA protein binds to both single-stranded and double stranded DNA and enhances ATPase activity of RuvB. RuvA and RuvB promote branch migration whereas RuvC resolves junctions by endonucleolytic cleavage. Moreover RuvAB stimulate Holliday junction resolution by RuvC. The RuvA-RuvB complex interacts with an irregular conformation in damaged DNA and induces conformational changes in DNA using energy provided by ATP hydrolysis, so that it facilitates DNA repair, recombination and error prone replication. RuvABC proteins are responsible for the occurrence of DSBs at arrested replication forks. In cells proficient for RecBC, RuvAB is uncoupled from RuvC and DSBs may be prevented. -
Synonyms
Crossover junction endodeoxyribonuclease ruvC;Holliday junction nuclease ruvC;Holliday junction resolvase ruvC;RuvC
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| RUVC-1336S | Recombinant Streptomyces coelicolor A3(2) RUVC protein, His-tagged | E.Coli/Yeast | Streptomyces coelicolor A3(2) | His |
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| ruvC-133E | Recombinant E. coli RuvC | E.coli | E.coli | Non |
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| RuvC-2666E | Recombinant E. coli Holliday Junction DNA Helicase RuvC | E.coli | E.coli | Non |
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| RUVC-2517A | Recombinant Akkermansia Muciniphila RUVC Protein (1-167 aa), His-Myc-tagged | E.coli | Akkermansia Muciniphila | His&Myc | 1-167 aa |
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| ruvC-4233E | Recombinant Escherichia coli ruvC protein, His-SUMO-tagged | E.coli | E.coli | His&SUMO | 2-173aa |
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Involved Pathway
RuvC involved in several pathways and played different roles in them. We selected most pathways RuvC participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with RuvC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
RuvC has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by RuvC itself. We selected most functions RuvC had, and list some proteins which have the same functions with RuvC. You can find most of the proteins on our site.
| Function | Related Protein |
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Interacting Protein
RuvC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RuvC here. Most of them are supplied by our site. Hope this information will be useful for your research of RuvC.
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