RRAGB

  • Official Full Name

    Ras-related GTP binding B

  • Overview

    The mTORC1 kinase complex is a critical regulator of cell growth. Its activity is modulated by energy levels, growth factors, and amino acids via signaling through Akt, MAPK, and AMPK pathways. Recent studies found that the four related GTPases, RagA, Rag

  • Synonyms

    RRAGB;Ras-related GTP binding B;ras-related GTP-binding protein B;rag B;GTP-binding protein ragB;RAGB;bA465E19.1

Recombinant Proteins

  • Human
  • Mouse
  • Rhesus macaque
  • Rat
  • E.coli
  • Mammalian Cells
  • HEK293
  • His
  • Non
  • Avi
  • Fc
  • DDK
  • Myc

    Involved Pathway

    RRAGB involved in several pathways and played different roles in them. We selected most pathways RRAGB participated on our site, such as Cellular responses to stress,Energy dependent regulation of mTOR by LKB1-AMPK,Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with RRAGB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    IGF1R signaling cascade EIF4B,RRAGA,IGF2B,LAMTOR1,C7orf59,HBXIP
    Insulin receptor signalling cascade GRB10A,LAMTOR1,GRB10,RRAGA,C7orf59
    Gene Expression LSM10,QTRTD1,POP1,RBB4L,TRIM28,ZFP2,ZNF620,ZNF670,CTGF,EEF1G
    Energy dependent regulation of mTOR by LKB1-AMPK LAMTOR1,C7orf59,HBXIP,RRAGA
    Generic Transcription Pathway MED13A,ZNF192,COX7C,NR2F1A,ZNF839,ZNF71,ZNF79,ZNF738,ZNF697,ZNF74
    IRS-mediated signalling HBXIP,C7orf59,RRAGA,LAMTOR1
    Cellular responses to stress TERF2IP,CDKN2A,HIST2H3C,IGFBP7,HIF1AL,MINK1,CEBPB,ATG4A,RBBP7,RPS19BP1
    IRS-related events triggered by IGF1R LAMTOR1,C7orf59,HBXIP,IGF2B,RRAGA

    Protein Function

    RRAGB has several biochemical functions, for example, GTP binding,GTPase activity,guanyl ribonucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RRAGB itself. We selected most functions RRAGB had, and list some proteins which have the same functions with RRAGB. You can find most of the proteins on our site.

    Function Related Protein
    GTP binding GLUD1,TUBB5,TUBA1L,IRGQ2,ARL3L1,RAB42B,NMUR2,ARF6B,EIF2B2,MXB
    protein binding CAND1,SPRY4,NOLC1,PARP9,CCBE1,TCAP,MOCOS,LILRB3,USF1,INPP5D
    GTPase activity DNM2,GNAV1,GNAO1A,RAB25B,RHOG,ARL1,IIGP1,DIRAS1,RASL10A,RABL5

    Interacting Protein

    RRAGB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RRAGB here. Most of them are supplied by our site. Hope this information will be useful for your research of RRAGB.

    RRAGC;RRAGD;LAMTOR1;LAMTOR3

    Resources

    References

    • Oloumi, A; Lam, W; et al. Identification of genes differentially expressed in V79 cells grown as multicell spheroids. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY 78:483-492(2002).
    • Tsuda, T; Kusui, T; et al. Neuromedin B receptor activation causes tyrosine phosphorylation of p125(FAK) by a phospholipase C independent mechanism which requires p21(rho) and integrity of the actin cytoskeleton. BIOCHEMISTRY 36:16328-16337(1997).

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