RRAGB

  • Official Full Name

    Ras-related GTP binding B

  • Overview

    The mTORC1 kinase complex is a critical regulator of cell growth. Its activity is modulated by energy levels, growth factors, and amino acids via signaling through Akt, MAPK, and AMPK pathways. Recent studies found that the four related GTPases, RagA, Rag

  • Synonyms

    RRAGB;Ras-related GTP binding B;ras-related GTP-binding protein B;rag B;GTP-binding protein ragB;RAGB;bA465E19.1

Recombinant Proteins

  • Human
  • Mouse
  • Rhesus macaque
  • Rat
  • E.coli
  • Mammalian Cells
  • HEK293
  • His
  • Non
  • His&Fc&Avi
  • Myc&DDK

    Involved Pathway

    RRAGB involved in several pathways and played different roles in them. We selected most pathways RRAGB participated on our site, such as Cellular responses to stress,Energy dependent regulation of mTOR by LKB1-AMPK,Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with RRAGB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Generic Transcription Pathway ZNF729,ZNF23,MED10,ZKSCAN1,ZNF354B,ZNF287,NKX2,ZNF561,NR2C2,ZNF257
    IGF1R signaling cascade LAMTOR1,EIF4B,RRAGA,IGF2B,HBXIP,C7orf59
    IRS-mediated signalling C7orf59,HBXIP,LAMTOR1,RRAGA
    Energy dependent regulation of mTOR by LKB1-AMPK HBXIP,LAMTOR1,C7orf59,RRAGA
    Insulin receptor signalling cascade GRB10A,RRAGA,C7orf59,LAMTOR1,GRB10
    IRS-related events triggered by IGF1R C7orf59,IGF2B,HBXIP,LAMTOR1,RRAGA
    Cellular responses to stress ULK1A,CDKN2A,CBX8A,HSPA12B,RBB4L,LC3,WIPI2,EHMT2,DNAJC2,EEF1A1
    Gene Expression MTF2,OSGEP,DARS,COX18,ZNF445,POU2F1,ADARB1,ZNF41,ZNF224,JARID2B

    Protein Function

    RRAGB has several biochemical functions, for example, GTP binding,GTPase activity,guanyl ribonucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RRAGB itself. We selected most functions RRAGB had, and list some proteins which have the same functions with RRAGB. You can find most of the proteins on our site.

    Function Related Protein
    GTP binding RAB34,GCH1,TUBA4L,RAB1,RAB22A,NOLC1,PIGC,RASL11B,SEPT4A,SEPT7B
    GTPase activity RAC1,GNAI2,EEF1A1L1,GNAL,EIF5,TUBB2,HRAS,RAB31,DNM1A,GNAZ
    protein binding OIT3,RAD17,FAM124A,CCT3,NKD1,CRTC2,DR1,NAIF1,CNOT1,EPHA3

    Interacting Protein

    RRAGB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RRAGB here. Most of them are supplied by our site. Hope this information will be useful for your research of RRAGB.

    RRAGC;RRAGD;LAMTOR1;LAMTOR3

    Resources

    References

    • Oloumi, A; Lam, W; et al. Identification of genes differentially expressed in V79 cells grown as multicell spheroids. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY 78:483-492(2002).
    • Tsuda, T; Kusui, T; et al. Neuromedin B receptor activation causes tyrosine phosphorylation of p125(FAK) by a phospholipase C independent mechanism which requires p21(rho) and integrity of the actin cytoskeleton. BIOCHEMISTRY 36:16328-16337(1997).

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