RPIA
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Official Full Name
ribose 5-phosphate isomerase A -
Overview
The protein encoded by this gene is an enzyme, which catalyzes the reversible conversion between ribose-5-phosphate and ribulose-5-phosphate in the pentose-phosphate pathway. This gene is highly conserved in most organisms. The enzyme plays an essential role in the carbohydrate metabolism. Mutations in this gene cause ribose 5-phosphate isomerase deficiency. A pseudogene is found on chromosome 18. -
Synonyms
RPIA;ribose 5-phosphate isomerase A;ribose-5-phosphate isomerase;ribose 5 phosphate epimerase;EC 5.3.1.6;MGC103524;Phosphoriboisomerase;Ribose 5 phosphate isomerase;ribose 5-phosphate epimerase;RPI;RPIA_HUMAN;zgc:103524
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Chicken
- Rhesus macaque
- E.coli
- E.coli
- Mammalian Cell
- HEK293
- Yeast
- His
- Non
- GST
- His&Fc&Avi
Involved Pathway
RPIA involved in several pathways and played different roles in them. We selected most pathways RPIA participated on our site, such as Pentose phosphate pathway,Metabolic pathways,Carbon metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with RPIA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | PIP5K1AB,MTHFD2,DCK,PRODH2,GALCB,ALOX15,SMS,IDH3G,PON1,ETNK1 |
| Biosynthesis of amino acids | GOT2B,MAT2AA,TALDO1,ASL,THA1,GLUL,TPI1B,ALDOCB,TAT,BCAT1 |
| Pentose phosphate pathway | ALDOB,FBP2,deoC,PFKL,FBP1A,PRPS2,PGM2,ALDOC,ALDOCA,FBP1 |
| Carbon metabolism | IDH3G,ackA,MDH1AA,GPIB,ANI_1_2390104,PGLS,PRPS2,IDH2,GPT,GPR19 |
Protein Function
RPIA has several biochemical functions, for example, monosaccharide binding,protein binding,ribose-5-phosphate isomerase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RPIA itself. We selected most functions RPIA had, and list some proteins which have the same functions with RPIA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| monosaccharide binding | GPI,PGLS,GPI1,GPR19,FBP1,Siglece,UPK1A,TALDO1 |
| protein binding | RPL5,ITGA1,RAB17,CNO,MYLK2,ARMC2,KLRC4-KLRK1,OSBPL7,UBL4A,MZB1 |
Interacting Protein
RPIA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RPIA here. Most of them are supplied by our site. Hope this information will be useful for your research of RPIA.
STK16;PTPN11;WDYHV1;GORASP2;PCMT1;CENPP
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References
- Kaur, PK; Dinesh, N; et al. Identification and characterization of a novel Ribose 5-phosphate isomerase B from Leishmania donovani. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 421:51-56(2012).
