RNPS1
-
Official Full Name
RNA binding protein S1, serine-rich domain -
Overview
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. This protein contains many serine residues. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013] -
Synonyms
RNPS1;RNA binding protein S1, serine-rich domain;E5.1;RNA-binding protein with serine-rich domain 1;SR protein;SR-related protein LDC2;RNA-binding protein S1, serine-rich domain
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Rat
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- T7
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
RNPS1 involved in several pathways and played different roles in them. We selected most pathways RNPS1 participated on our site, such as Cleavage of Growing Transcript in the Termination Region,Gene Expression,Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), which may be useful for your reference. Also, other proteins which involved in the same pathway with RNPS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Nonsense-Mediated Decay (NMD) | SMG9,SMG8 |
| Processing of Capped Intron-Containing Pre-mRNA | WTAP,PTBP1A,RBM5,HNRNPH1,HNRNPA2B1,CSTF2,YBX1,SF3A3,HNRNPH1L,ZMAT5 |
| Cleavage of Growing Transcript in the Termination Region | LSM11,CSTF1,SRSF11,NUDT21,CLP1,CSTF2,SLBP,U2AF2,LSM10,ZFP473 |
| RNA Polymerase II Transcription Termination | ZFP473,CSTF3,LSM10,PAPOLA,CSTF2,CSTF1,THOC4,SRSF11,ZNF473,U2AF2 |
| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | SMG8,SMG9 |
| RNA Polymerase II Transcription | CSTF1,ZFP473,U2AF2,CCNT2A,LSM11,GM3258,SLBP,CLP1,NUDT21,SRSF11 |
| RNA transport | PABPC1B,EIF2B5,EIF5,EIF4EA,CASC3,NXF2,PABPC5,NUP88,XPO5,EIF4G1A |
| Gene Expression | ZNF213,MTA1,KHSRP,ZFP90,UBTF,ZNF573,SLBP,SKIA,RARAA,MBD3 |
Protein Function
RNPS1 has several biochemical functions, for example, NOT RNA binding,mRNA 3-UTR binding,nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RNPS1 itself. We selected most functions RNPS1 had, and list some proteins which have the same functions with RNPS1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | PTRF,MRPS21,NTPCR,MKI67,ALDH6A1,ZFP598,TFAM,HSP90AB1,HNRPLL,TNPO1 |
| nucleotide binding | GUCY2F,RND3B,RNPC3,FGFR1A,SEPT8A,EIF3G,ARL4AA,POLR2D,ABCA4,RBM33 |
| NOT RNA binding | NCBP2 |
| protein binding | HDAC4,NLRC5,EPHA7,GPR77,ZNF207,PDCD2,TTR,CCDC36,C14orf169,TDRD9 |
| mRNA 3-UTR binding | CIRBP,PPP1R2P9,RIMS2,RNF40,ELAVL4,ELAVL2,CPEB4,CPEB1A,TARDBP,PARN |
Interacting Protein
RNPS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RNPS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RNPS1.
SRPK1;UPF3B;SART3;YWHAG;THRAP3;SRPK2;U2AF1;SRSF1
Resources
Related Services
Related Products
References
