RHOG
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Official Full Name
ras homolog gene family, member G (rho G) -
Overview
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein facilitates translocation of a functional guanine nucleotide exchange factor (GEF) complex from the cytoplasm to the plasma membrane where ras-related C3 botulinum toxin substrate 1 is activated to promote lamellipodium formation and cell migration. Two related pseudogene have been identified on chromosomes 20 and X. -
Synonyms
RHOG;ras homolog gene family, member G (rho G);ARHG;rho-related GTP-binding protein RhoG;MGC125835;MGC125836;Rho related GTP binding protein RhoG precursor;RHOG_HUMAN
Recombinant Proteins
- Mouse
- Chicken
- Human
- Rhesus macaque
- Mammalian Cells
- E.coli
- HEK293
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| RHOG-14175M | Recombinant Mouse RHOG Protein | Mammalian Cells | Mouse | His |
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| RHOG-1910C | Recombinant Chicken RHOG | Mammalian Cells | Chicken | His |
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| RHOG-30980TH | Recombinant Human RHOG, His-tagged | E.coli | Human | His | 32-191 a.a. |
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| RHOG-3888R | Recombinant Rhesus monkey RHOG Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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| RHOG-6843H | Recombinant Human Ras Homolog Family Member G, His-tagged | E.coli | Human | His | 1-188aa |
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| RHOG-542HCL | Recombinant Human RHOG lysate | HEK293 | Human | Non |
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| RHOG-3705R | Recombinant Rhesus Macaque RHOG Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| RHOG-3705R-B | Recombinant Rhesus Macaque RHOG Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| RHOG-683H | Recombinant Human RHOG protein, His-tagged | E.coli | Human | His | 74-191 aa |
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| RHOG-7590M | Recombinant Mouse RHOG Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| RHOG-7590M-B | Recombinant Mouse RHOG Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
RHOG involved in several pathways and played different roles in them. We selected most pathways RHOG participated on our site, such as Bacterial invasion of epithelial cells,Shigellosis,Salmonella infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with RHOG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Salmonella infection | MYD88,RELA,CXCL1,NOS2,DYNC2H1,DYNC1I2A,TLR4BA,IFNG1-2,RAB7,NFKB1 |
| Bacterial invasion of epithelial cells | ARPC2,CRK,HCLS1,SEPT2,DNM1,CTNNA2,SEPT3,WASF1,FN1,PXN |
| Shigellosis | ELMO1,PFN2,MAPK13,RELA,PFN1,ABL1,CDC42,ELMO2,MAPK9,PFN4 |
Protein Function
RHOG has several biochemical functions, for example, GTP binding,GTPase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RHOG itself. We selected most functions RHOG had, and list some proteins which have the same functions with RHOG. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTP binding | C9orf86,RAB1A,RAB20,SEPT5B,ARL3L1,SEPT9B,RAB11AL,ARF1L,GTPBP5,RAB11BB |
| GTPase activity | EIF5B,EEF2A.2,MXC,ARL2,NKIRAS1,GFM1,GSPT1L,RHOQ,GNA13B,DNM2 |
| protein binding | DPYSL4,KRTAP23-1,ITGA7,AJUBA,DDX19B,DNAJB6,AKAP12,DEFA6,KRTAP10-11,OTX2 |
Interacting Protein
RHOG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RHOG here. Most of them are supplied by our site. Hope this information will be useful for your research of RHOG.
ELMO1;1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate;pi3p;ATP6AP2;RAB7A;DOCK1;Coro1c
Resources
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References
- Samson, T; van Buul, JD; et al. The Guanine-Nucleotide Exchange Factor SGEF Plays a Crucial Role in the Formation of Atherosclerosis. PLOS ONE 8:-(2013).
- Faugaret, D; Chouinard, FC; et al. An essential role for phospholipase D in the recruitment of vesicle amine transport protein-1 to membranes in human neutrophils. BIOCHEMICAL PHARMACOLOGY 81:144-156(2011).
