RGS20
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Official Full Name
regulator of G-protein signaling 20 -
Overview
The protein encoded by this gene belongs to the family of regulator of G protein signaling (RGS) proteins, which are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins inhibit signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound forms. This protein selectively binds to G(z)-alpha and G(alpha)-i2 subunits, and regulates their signaling activities. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
RGS20;regulator of G-protein signaling 20;regulator of G protein signalling 20;RGSZ1;ZGAP1;G(z)GAP;Gz selective GTPase activating protein;HGNC:14600;Regulator of G protein signaling 20;Regulator of Gz selective protein signaling 1;gz-GAP;OTTHUMP00000227381;OTTHUMP00000227383;OTTHUMP00000227397;regulator of G-protein signaling Z1;regulator of G-protein signalling 20;gz-selective GTPase-activating protein;regulator of Gz-selective protein s
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- His
- Non
- GST
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| RGS20-2279H | Recombinant Human RGS20, His-tagged | E.coli | Human | His | C-term-234aa | |
| RGS20-565Z | Recombinant Zebrafish RGS20 | Mammalian Cells | Zebrafish | His |
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| RGS20-6405C | Recombinant Chicken RGS20 | Mammalian Cells | Chicken | His |
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| RGS20-2377HCL | Recombinant Human RGS20 293 Cell Lysate | HEK293 | Human | Non |
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| RGS20-2654H | Recombinant Human RGS20 Protein, His-tagged | E.coli | Human | His | Met1-Ala388 |
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| RGS20-3428H | Recombinant Human RGS20 protein, GST-tagged | E.coli | Human | GST | 1-234aa |
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| Rgs20-5497M | Recombinant Mouse Rgs20 Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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Involved Pathway
RGS20 involved in several pathways and played different roles in them. We selected most pathways RGS20 participated on our site, such as Calcium Regulation in the Cardiac Cell,G alpha (i) signalling events,G alpha (z) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with RGS20 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signal Transduction | GPR161,IQGAP3,ARHGEF25,RCA2.1,GRB10A,RTN4A,PDK3,RDH14B,RLN3A,ABHD6B |
| G alpha (i) signalling events | CNR1,CCL35.1,ADRA2B,OXGR1A.2,FPR-RS6,APPB,GPR55A,NMUR1,PTGDR2,RGS21 |
| GPCR downstream signaling | PTH,EDNRB,GPR132B,NMU,ADRA2B,TAS2R3,ADRA2C,RHOL,ADCYAP1R1,DGKQ |
| Signaling by GPCR | KISS1,VIP,ANXA1B,RAMP3,TAS2R13,RLN2,PTHLH,GPBAR1,NMBA,ARHGEF18A |
| G alpha (z) signalling events | RGS19,ADRA2B,RGS17,RGS4,ADRA2C,ADRA2A |
| Calcium Regulation in the Cardiac Cell | PKIB,CX55.5,RGS7,GJB5,ADRa1A,CHRM4,GJA8,CHRM3,CASQ2,RGS18 |
| Myometrial Relaxation and Contraction Pathways | GPR182,RGS7,PKIG,GABPB1,MAFF,RGS19,GUCA2B,ADM,RGS4,RAMP3 |
Protein Function
RGS20 has several biochemical functions, for example, GTPase activator activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RGS20 itself. We selected most functions RGS20 had, and list some proteins which have the same functions with RGS20. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ITGB3BP,CIAPIN1,ZBTB48,CLK4,EPC1,GOLGA1,KCTD1,SCNM1,FAM9C,PUM1 |
| GTPase activator activity | ARAP3,RIN3,TBC1D2B,ELMOD2,CDC42EP1B,FAM13A,ARFGAP2,TSC2,RGS17,TBC1D22B |
Interacting Protein
RGS20 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RGS20 here. Most of them are supplied by our site. Hope this information will be useful for your research of RGS20.
GLRX3;OTX1;CATSPER1;MTNR1A;Hoxa1
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References
- Walther, S; Strittmatter, F; et al. Expression and Alpha1-adrenoceptor Regulation of Caldesmon in Human Prostate Smooth Muscle. UROLOGY 79:-(2012).
- Rivero, G; Gabilondo, AM; et al. Characterization of regulators of G-protein signaling RGS4 and RGS10 proteins in the postmortem human brain. NEUROCHEMISTRY INTERNATIONAL 57:722-729(2010).
