RELA
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Official Full Name
v-rel reticuloendotheliosis viral oncogene homolog A -
Overview
Transcription factor p65 is a protein that in humans is encoded by the RELA gene. NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA, or RELB (MIM 604758) to form the NF-κB complex. The p50 (NFKB1)/p65 (RELA) heterodimer is the most abundant form of NF-κB. The NF-κB complex is inhibited by IκB (NFKBIA, MIM 164008 or NFKBIB, MIM 604495), which inactivate NF-κB by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-κB complex. Activated NF-κB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM] -
Synonyms
RELA;v-rel reticuloendotheliosis viral oncogene homolog A (avian);NFKB3;p65;Nuclear factor NF-kappa-B p65 subunit;MGC131774;transcription factor p65;OTTHUMP00000233473;OTHUMP00000233474;OTTHUMP00000233475;OTTHUMP00000233476;OTTHUMP00000233900;nuclear factor of kappa light polypeptide gene enhancer in B-cells 3;v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65;v-rel avian reticuloendotheliosis;viral oncogene homolog A (nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 (p65))
Recombinant Proteins
- Human
- Bacillus subtilis
- Mouse
- Zebrafish
- Chicken
- E.coli
- E.Coli/Yeast
- Mammalian Cells
- Wheat Germ
- Sf21 Cells
- HEK293
- Insect Cells
- Non
- GST
- His
- T7
- Flag
- Avi
- Fc
- DDK
- Myc
Involved Pathway
RELA involved in several pathways and played different roles in them. We selected most pathways RELA participated on our site, such as MAPK signaling pathway,Ras signaling pathway,cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RELA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Toxoplasmosis | HSPA8,HLA-DQB1,LAMB4,Toxoplasma Gondii Dense Granule Protein 7,TAB2,HLA-DPA1,Toxoplasma Gondii Major Surface Antigen P30,ALOX5,GNAI2,HLA-DRB3 |
| NOD-like receptor signaling pathway | PYDC1,NLRP3,MAPK3,MAPK8B,MAPK11,NAIP6,HSP90AA1.2,CARD18,HSP90AA1,TNFAIP3 |
| Pancreatic cancer | MAPK3,CASP9,PIK3CA,TGFB2,STAT1,BAD,PIK3R2,ERBB2,NFKB1,PIK3R5 |
| Tuberculosis | RIPK2,HLA-DMA,CD14,LAMP2,HLA-DQB1,IFNA7,ITGAM,NFYA,CALM2,PPP3CA |
| Chemokine signaling pathway | GNAI3,JAK3,RAP1A,CRKL,CXCR4,NFKB1,GSK3A,CCL3L3,LOC100033925,BCAR1 |
| Chronic myeloid leukemia | RUNX1,CBLC,SHC1,TGFB2,GRB2,PTPN11,CDK6,ABL1,SMAD3,PIK3R5 |
| B Cell Receptor Signaling Pathway | LILRB3,PPP3CA, Cd79b,SOS1,ACTR3,NFKBIA,CRKL,CD72,RAP2A,CR2 |
| Epstein-Barr virus infection | TP53,HLA-DPA1,PIK3CA,TRP53,HDAC1,PSMD8,HSPA1B,PSMD2,PRKACG,RIPK1 |
| Transcriptional misregulation in cancer | HIST1H3G,MLF1,HIST2H3C1,MLLT3,RXRG,ETV1,SIX1,DEFA3,PLAT,BCL6 |
Protein Function
RELA has several biochemical functions, for example, DNA binding,NF-kappaB binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RELA itself. We selected most functions RELA had, and list some proteins which have the same functions with RELA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II distal enhancer sequence-specific DNA binding | H2AFZ,TFAP2C,NONO,HOXB5,PROP1,SFPI1,CDX1,FLI1,JUN,SPI1 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | NR5A2,FIGLA,PATZ1,EGR1,TP73,MEF2B,DDIT3,FOSL1,NKX2-8,MYBL2 |
| repressing transcription factor binding | KAT5,NFYB,MAGEA2,HDAC5,PARK7,TCF3,CTBP1,DDX20,HDAC9,SKI |
| transcription factor binding | ARRB1,HDAC3,HOXA7,DRG1,APBB1,ENPP2,EPN1,RBFOX2,CREBBP,GTF2F1 |
| NF-kappaB binding | CDK5RAP3,BCL10,HSPA6,MTDH,HIF1AN,RPS3,RNF25,COMMD6,GSK3B,COMMD7 |
| phosphate ion binding | RPH3A,PNP,ADSSL1,SH2B3,OTC,CHST14,G6PC,ADSS,SLC34A2,GNG12 |
| actinin binding | PKD2,NFKB1,MICALL2,CSRP3,PDLIM5,TTN,PROM1 |
| protein complex binding | TUBB,PDZK1,MYSM1,KAT6B,CCNE1,SLC9A3R1,ATP6V1B1,DRD1A,LRP1,FYB |
| transcription factor activity, sequence-specific DNA binding | FOXG1D,RXRAA,ZIC5,PCGF2,PAX8,HOXA4A,CDX1B,SUPT4H1,ZNF500,ZNF232 |
Interacting Protein
RELA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RELA here. Most of them are supplied by our site. Hope this information will be useful for your research of RELA.
NFKBIA
RELA Related Signal Pathway
Resources
Research Area
Apoptosis Transcription Factors and RegulatorsInflammatory Mediators
Transcription Factors in the Akt Pathway
NFkB
Natural Killer T (NKT) Cells
Inflammatory Bowel Diseases Therapeutic Targets
C-type Lectin Receptors
NOD-like Receptors and the Inflammasome
RIG-I-like Receptors
IL-1 Family Signaling Molecules
IL-17 Signaling Related Molecules
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References
- Yang, HJ; Wang, M; et al. NF-kappa B Regulates Caspase-4 Expression and Sensitizes Neuroblastoma Cells to Fas-Induced Apoptosis. PLOS ONE 10:-(2015).
- Chen, Y; Lu, RQ; et al. The NFKB1 polymorphism (rs4648068) is associated with the cell proliferation and motility in gastric cancer. BMC GASTROENTEROLOGY 15:-(2015).
