REG1A
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Official Full Name
regenerating islet-derived 1 alpha -
Overview
This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped into four subclasses, types I, II, III and IV, based on the primary structures of the encoded proteins. This gene encodes a protein that is secreted by the exocrine pancreas. It is associated with islet cell regeneration and diabetogenesis and may be involved in pancreatic lithogenesis. Reg family members REG1B, REGL, PAP and this gene are tandemly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication. -
Synonyms
REG1A;regenerating islet-derived 1 alpha;REG, regenerating islet derived 1 alpha (pancreatic stone protein, pancreatic thread protein);lithostathine-1-alpha;pancreatic stone protein;pancreatic thread protein;PSP;PSPS;PSPS1;PTP;ICRF;Islet cells regeneration factor;Islet of Langerhans regenerating protein;Lithostathine 1 alpha;Lithostathine 1 alpha precursor;MGC12447;P19;Pancreatic stone protein secretory;Protein X;REG;Regenerating islet derived 1 alpha;Regenerating islet derived 1 alpha pancreatic stone protein pancreatic thread protein;Regenerating protein I alpha;protein-X;REG-1-alpha;OTTHUMP00000160485;pancreatic stone protein, secretory;regene
Recombinant Proteins
- Human
- Rat
- Rhesus macaque
- Cynomolgus
- HEK293
- E.coli
- Mammalian Cell
- Human Cell
- Mammalian cells
- His
- His&T7
- Fc
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
REG1A involved in several pathways and played different roles in them. We selected most pathways REG1A participated on our site, such as Insulin Signaling,Type II interferon signaling (IFNG), which may be useful for your reference. Also, other proteins which involved in the same pathway with REG1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Insulin Signaling | CAP1,STXBP3,GSK3AB,SNAP25A,MYO1C,MAP4K5,GRB10,RHOJ,MAP3K9,MAPK6 |
| Type II interferon signaling (IFNG) | IFI6,IFIT2,Ifna,GBP1 |
Protein Function
REG1A has several biochemical functions, for example, carbohydrate binding,growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by REG1A itself. We selected most functions REG1A had, and list some proteins which have the same functions with REG1A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| carbohydrate binding | REG1B,CD69,PYGM,ZG16B,Il2,CHIA,MAN2C1,GALNT2,KLRF1,GALNT1 |
| growth factor activity | RABEP2,AMH,FGF8A,FGF1,FGF10,VEGFA,CECR1A,BMP6,OSM,VEGFAB |
Interacting Protein
REG1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with REG1A here. Most of them are supplied by our site. Hope this information will be useful for your research of REG1A.
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References
