RASSF5
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Official Full Name
Ras association (RalGDS/AF-6) domain family member 5 -
Overview
This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
RASSF5;Ras association (RalGDS/AF-6) domain family member 5;RAPL;Maxp1;NORE1;NORE1A;NORE1B;RASSF3;MGC10823;MGC17344;Ras association domain-containing protein 5;New ras effector 1;Regulator for cell adhesion and polarization enriched in lymphoid tissues;OTTHUMP00000034534;OTTHUMP00000034535;Rap1-binding protein;Ras association (RalGDS/AF-6) domain family 5;Ras effector-like protein;novel Ras effector 1;tumor suppressor RASSF3
Recombinant Proteins
- Human
- Mouse
- Chicken
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| RASSF5-1071H | Recombinant Human RASSF5, GST-tagged | E.coli | Human | GST |
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| RASSF5-13967M | Recombinant Mouse RASSF5 Protein | Mammalian Cells | Mouse | His |
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| RASSF5-1830C | Recombinant Chicken RASSF5 | Mammalian Cells | Chicken | His |
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| RASSF5-29658TH | Recombinant Human RASSF5, His-tagged | E.coli | Human | His | 35-260 a.a. |
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| RASSF5-29726TH | Recombinant Human RASSF5 | E.coli | Human | Non | 188-390 a.a. |
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| RASSF5-5443H | Recombinant Human RASSF5, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| RASSF5-2495HCL | Recombinant Human RASSF5 293 Cell Lysate | HEK293 | Human | Non |
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| RASSF5-4638H | Recombinant Human RASSF5 protein, GST-tagged | E.coli | Human | GST | 1-265aa |
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| Rassf5-5397M | Recombinant Mouse Rassf5 Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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| RASSF5-7449M | Recombinant Mouse RASSF5 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| RASSF5-7449M-B | Recombinant Mouse RASSF5 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
RASSF5 involved in several pathways and played different roles in them. We selected most pathways RASSF5 participated on our site, such as Ras signaling pathway,Rap signaling pathway,Leukocyte transendothelial migration, which may be useful for your reference. Also, other proteins which involved in the same pathway with RASSF5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ras signaling pathway | RAC3,IGF1,RAB5C,HRAS,RASGRF2,LAT,RAP1A,GNG10,CSF1,INS |
| Pathways in cancer | GNB1,LAMB1,SFPI1,CBLB,FASLG,FH1,LEF1,LAMB2,AHA-1,GLI1 |
| Leukocyte transendothelial migration | EZR,CLDN7,THY1,VAV2,ROCK1,MAPK13,MMP9,NOX3,PTK2B,VCAM1 |
| Rap signaling pathway | VASP,FGF13,PIK3CB,F2R,PDGFC,LPAR2,MAPK3,NRAS,FGFR1,PIK3R2 |
| Non-small cell lung cancer | RXRA,STK4,PIK3CB,PIK3R3,PIK3CG,BRAF,AKT2,PRKCA,PIK3CD,PIK3R2 |
Protein Function
RASSF5 has several biochemical functions, for example, metal ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RASSF5 itself. We selected most functions RASSF5 had, and list some proteins which have the same functions with RASSF5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | SPN,CRCP,C1QTNF9,MRC1,TBX5,BNIP1,MPZL2B,MYCBP,DCC,ADAM12 |
| metal ion binding | IRF2BP2A,MORC2B,GTPBP6,ZFP516,NGB,KITA,ARAP1,NR5A1A,GALNT4,ZNF335 |
Interacting Protein
RASSF5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RASSF5 here. Most of them are supplied by our site. Hope this information will be useful for your research of RASSF5.
STK3;STK4;MAP1LC3B;HRAS
RASSF5 Related Signal Pathway
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References
- Guo, W; Wang, C; et al. RASSF5A, a candidate tumor suppressor, is epigenetically inactivated in esophageal squamous cell carcinoma. CLINICAL & EXPERIMENTAL METASTASIS 32:83-98(2015).
- Schmidt, ML; Donninger, H; et al. Ras Regulates SCF beta-TrCP Protein Activity and Specificity via Its Effector Protein NORE1A. JOURNAL OF BIOLOGICAL CHEMISTRY 289:31102-31110(2014).
