RASGRP2
-
Official Full Name
RAS guanyl releasing protein 2 (calcium and DAG-regulated) -
Overview
The protein encoded by this gene is a brain-enriched nucleotide exchanged factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. This protein can activate small GTPases, including RAS and RAP1/RAS3. The nucleotide exchange activity of this protein can be stimulated by calcium and diacylglycerol. Three alternatively spliced transcript variants encoding the same protein have been found for this gene. -
Synonyms
RASGRP2;RAS guanyl releasing protein 2 (calcium and DAG-regulated);RAS guanyl-releasing protein 2;CALDAG GEFI;hCDC25L;cdc25-like protein;F25B3.3 kinase-like protein;guanine exchange factor MCG7;RAS guanyl nucleotide-releasing protein 2;calcium an
Recombinant Proteins
- Mouse
- Human
- Rhesus macaque
- Mammalian Cells
- E.coli
- HEK293
- His
- Myc&DDK
- Non
- His&Fc&Avi
- Flag
Involved Pathway
RASGRP2 involved in several pathways and played different roles in them. We selected most pathways RASGRP2 participated on our site, such as Adaptive Immune System,Chemokine signaling pathway,Effects of PIP2 hydrolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with RASGRP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Effects of PIP2 hydrolysis | TRPC7,ABHD6B,TRPC6A,MGLL,ABHD12,DGKB,PRKCHB,DGKQ,DGKG,TRPC3 |
| Fc epsilon receptor (FCERI) signaling | ITK,LCP2A,TAB1,GRAP2A,GRAP2B,LAT2 |
| Adaptive Immune System | LILRA3,GRAP2A,CMTM2A,SRMS,PAG1,SPTBN2,UBE2F,DTX3L,DZIP3,AGO2 |
| G alpha (q) signalling events | ANXA1B,TRPC7,FPR-RS6,OPN4.1,LTB4R,PROKR1A,CHRM3,OXTRL,EDNRB,CYSLTR1 |
| GPCR downstream signaling | PYYA,PENKB,ANXA1A,TAAR1,DRD2,FFAR3,ANXA1,SSTR5,NPFF,CHRM5 |
| Chemokine signaling pathway | CCL25,CXCL13,GNG5,CCL4,CXCR5,RLN1,CRK,PF4V1,GNG8,LOC100033925 |
| Gastrin-CREB signalling pathway via PKC and MAPK | UTS2D,NMBB,RGS18,EDN3,KISS1,PROK2,TRPC6A,ABHD12,NMBA,MLN |
| FCERI mediated NF-kB activation | TAB1 |
Protein Function
RASGRP2 has several biochemical functions, for example, calcium ion binding,diacylglycerol binding,guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RASGRP2 itself. We selected most functions RASGRP2 had, and list some proteins which have the same functions with RASGRP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| diacylglycerol binding | UNC13A,UNC13C,TRPC2,CDIPT,UNC13B,RASGRP1,RASGRP4,RASGRP3 |
| lipid binding | PAQR7B,FABP1A,CRABP2B,BPIFB6,APOL6,MAL,RBP2A,PTGS1,PAQR5A,PITPNM2 |
| calcium ion binding | PCDHAC2,F9B,ZZEF1,PCDHA6,FBN2,RCVRN,EFHC2,DSG1C,SPNA2,TTYH1 |
| guanyl-nucleotide exchange factor activity | EIF2B5,ARHGEF7B,VAV2,SERGEF,RALGPS2,VAV1,FGD6,SH2D3C,TBXA2R,RASGEF1BA |
Interacting Protein
RASGRP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RASGRP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of RASGRP2.
q5nf52_fratt;FAM118B;PTCHD2
Resources
Related Services
Related Products
References
