RAP1GAP
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Official Full Name
RAP1 GTPase activating protein -
Overview
This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct proteins. -
Synonyms
RAP1GAP;RAP1 GTPase activating protein;RAP1, GTPase activating protein 1 , RAP1GA1;rap1 GTPase-activating protein 1;KIAA0474;RAP1GAP1;RAP1GAPII;Rap1 GTPase activating protein 1;RAP1GA1;Rap1ga1 protein;RAPGAP;OTTHUMP00000008709;OTTHUMP00000008710;OTTHUMP00000008711;OTTHUMP00000008712
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| RAP1GAP-1129H | Recombinant Human RAP1 GTPase Activating Protein | E.coli | Human | Non |
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| RAP1GAP-30503TH | Recombinant Human RAP1GAP, His-tagged | E.coli | Human | His | Full L. 1-663 a.a. |
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| RAP1GAP-6629Z | Recombinant Zebrafish RAP1GAP | Mammalian Cells | Zebrafish | His |
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| RAP1GAP-2527HCL | Recombinant Human RAP1GAP 293 Cell Lysate | HEK293 | Human | Non |
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| RAP1GAP-3334H | Recombinant Human RAP1GAP Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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| Rap1gap-466M | Recombinant Mouse Rap1gap Protein, MYC/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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Involved Pathway
RAP1GAP involved in several pathways and played different roles in them. We selected most pathways RAP1GAP participated on our site, such as Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAP1GAP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Rap signaling pathway | PFN1,BCAR1,VAV2,CALM1,IGF1,AKT2,PARD3,GRIN2B,RALB,GNAI3 |
Protein Function
RAP1GAP has several biochemical functions, for example, GTPase activator activity,GTPase activity,Ras GTPase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RAP1GAP itself. We selected most functions RAP1GAP had, and list some proteins which have the same functions with RAP1GAP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| Ras GTPase binding | MLLT4,PLCE1,RASGRP3,CIB1,SPHK2,RIN1,SH3BP4,RAPGEF4,RGL3,RAPGEF6 |
| GTPase activity | GSPT1L,GNAQ,RAB1BA,RAB14L,RND3,GNAO1,ARF3,RAB35,GNL3,AGAP2 |
| protein binding | FGF1,SCARB1,CPNE6,GGA2,BAG5,CLEC1B,CTNNBL1,CRYAA,FAS,ZNRF1 |
| protein homodimerization activity | KIF20B,ANG,XCL1,ACAT1,MAFA,HSD17B4,GALE,HOMER2,CTBP2A,ADIPOQ |
| GTPase activator activity | ARHGAP28,TBC1D10B,ARHGAP23,MURC,ARHGAP18,TBC1D3B,TSC2,SRGAP2A,BCR,PLEKHG6 |
Interacting Protein
RAP1GAP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAP1GAP here. Most of them are supplied by our site. Hope this information will be useful for your research of RAP1GAP.
RAP1B;Dlg4;YWHAZ;DYNC1I1;PFN2;CSNK1G2;MAPK6;MEX3B;MAP1LC3B
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