RANGAP1
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Official Full Name
Ran GTPase activating protein 1 -
Overview
RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1,000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88% identical to Fug1, the murine homolog of yeast Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle. -
Synonyms
RANGAP1;Ran GTPase activating protein 1;SD, segregation distorter homolog (Drosophila);ran GTPase-activating protein 1;Fug1;KIAA1835;segregation distortion;segregation distorter homolog;SD;MGC20266
Recombinant Proteins
- Human
- Chicken
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- Mamanlian cells
- HEK293T
- In Vitro Cell Free System
- His
- GST
- Myc&DDK
- Non
- Flag
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| RANGAP1-3117H | Recombinant Human RANGAP1 protein, His-tagged | E.coli | Human | His | 2-220 aa | |
| RANGAP1-1384C | Recombinant Chicken RANGAP1 | Mammalian Cell | Chicken | His |
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| RANGAP1-13916M | Recombinant Mouse RANGAP1 Protein | Mammalian Cell | Mouse | His |
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| RANGAP1-30474TH | Recombinant Human RANGAP1, His-tagged | E.coli | Human | His | Full L. 1-357 a.a. |
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| RANGAP1-38H | Recombinant Human RANGAP1 protein, GST-tagged | Wheat Germ | Human | GST | 1-587 a.a. |
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| RANGAP1-42H | Recombinant Human RANGAP1 protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| RANGAP1-682H | Recombinant Human Ran GTPase Activating Protein 1, GST-tagged | E.coli | Human | GST |
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| RANGAP1-2532HCL | Recombinant Human RANGAP1 293 Cell Lysate | HEK293 | Human | Non |
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| RANGAP1-12H | Recombinant Human RANGAP1 Protein, His-tagged | E.coli | Human | His | 418-end a.a. |
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| RANGAP1-4293HFL | Recombinant Full Length Human RANGAP1 protein, Flag-tagged | Mamanlian cells | Human | Flag | Full L. |
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| Rangap1-5370M | Recombinant Mouse Rangap1 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| RANGAP1-706HF | Recombinant Full Length Human RANGAP1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 587 amino acids |
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| RANGAP1-7416M | Recombinant Mouse RANGAP1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| RANGAP1-7416M-B | Recombinant Mouse RANGAP1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
RANGAP1 involved in several pathways and played different roles in them. We selected most pathways RANGAP1 participated on our site, such as RNA transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with RANGAP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RNA transport | NXF2,EIF2S3Y,NUP133,PEAK1,NUP210,EEF1A2,EIF4A1B,EIF2B3,EIF2S1B,NCBP1 |
Protein Function
RANGAP1 has several biochemical functions, for example, GTPase activator activity,Ran GTPase binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RANGAP1 itself. We selected most functions RANGAP1 had, and list some proteins which have the same functions with RANGAP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| Ran GTPase binding | XPOT,TNPO2,XPO1,IPO4,XPO5,NXT1,IPO8,KPNB1,BIRC5,IPO5 |
| protein binding | MFAP4,MYH11,NKAP,EID1,TBATA,TRP53,GRID2IP,NLRP12,BCL2L14,ANKMY2 |
| ubiquitin protein ligase binding | DIO2,PML,Fzd4,NDUFS2,POU5F1,PACRG,UBE2KA,TRIB1,CUL2,BAG5 |
| GTPase activator activity | TBC1D16,TBC1D1,TBC1D3,RGS3A,RGS2,TBC1D17,ARHGAP26,ALDH1A2,TBC1D10A,RGS13 |
Interacting Protein
RANGAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RANGAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RANGAP1.
UBE2I;SUMO1;Ranbp2;NXF1;GNAI1;HLA-B;GABARAPL2
Resources
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References
- Berndt, A; Wilkinson, KA; et al. In vivo characterization of the properties of SUM01-specific monobodies. BIOCHEMICAL JOURNAL 456:385-395(2013).
- Tang, YA; Mackey, J; et al. Quantitative proteomic analysis of HER2 normal and overexpressing MCF-7 breast cancer cells revealed proteomic changes accompanied with HER2 gene amplification. JOURNAL OF PROTEOMICS 91:200-209(2013).
