RAI1
-
Official Full Name
retinoic acid induced 1 -
Overview
This gene is located within the Smith-Magenis syndrome region on chromosome 17. It is highly similar to its mouse counterpart and is expressed at high levels mainly in neuronal tissues. The protein encoded by this gene includes a polymorphic polyglutamine tract in the N-terminal domain. Expression of the mouse counterpart in neurons is induced by retinoic acid. This gene is associated with both the severity of the phenotype and the response to medication in schizophrenic patients. -
Synonyms
RAI1;retinoic acid induced 1;SMCR, Smith Magenis syndrome chromosome region;retinoic acid-induced protein 1;DKFZP434A139;KIAA1820;MGC12824;SMS;Smith-Magenis syndrome chromosome region;SMCR
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| RAI1-49H | Recombinant Human RAI1, GST-tagged | Wheat Germ | Human | GST |
|
Involved Pathway
RAI1 involved in several pathways and played different roles in them. We selected most pathways RAI1 participated on our site, such as Circadian Clock, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAI1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Circadian Clock | CRY2,CARM1,DBP,NAMPT,HELZ2,CSNK1E,CPT1A,NRIP1,CRY1 |
Protein Function
RAI1 has several biochemical functions, for example, enhancer binding,protein binding,transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RAI1 itself. We selected most functions RAI1 had, and list some proteins which have the same functions with RAI1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| zinc ion binding | TTF2,SYTL4,RNF13,CBLC,FHL1A,ZMIZ2,LPP,ZCCHC11,CNBPA,MDM2 |
| protein binding | ERGIC2,ICA1L,PRKD3,CRYBA2,MFF,DCPS,PHF20L1,H3F3B,GPSM2,AMPH |
| transcription factor activity, sequence-specific DNA binding | ZNF167,ZFP2,TAF1B,CTCF,FOXP4,ZNF334,ZNF561,ESRRGB,ZFP551,CNOT8 |
| enhancer binding | TCF3,SP1,FOXH1,TCF12,AHR,SMAD2,ELL3,TIPARP,LEF1,SMAD3 |
Interacting Protein
RAI1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAI1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RAI1.
PIN1;RPS6KA5;TTR;GADD45A;CDKN1A;CASP2;GSK3B;MAPK8IP2;ypwA;TESC;CDK2AP1;Cbx1;PYHIN1;Mta1;HMG20A;DAXX;TCF20
Resources
Related Services
Related Products
References
- Huang, HQ; Saravia, J; et al. Impaired gamma delta T cell-derived IL-17A and inflammasome activation during early respiratory syncytial virus infection in infants. IMMUNOLOGY AND CELL BIOLOGY 93:126-135(2015).
- Chen, QY; Ross, AC; et al. All-trans-retinoic acid and CD38 ligation differentially regulate CD1d expression and alpha-galactosylceramide-induced immune responses. IMMUNOBIOLOGY 220:32-41(2015).
