RAD17
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Official Full Name
RAD17 homolog -
Overview
The human checkpoint protein Rad17 and its fission and budding yeast orthologues (Schizosaccharomyces pombe Rad17 and Saccharomyces cerevisiae Rad24, respectively) are involved in the activation of checkpoint signals in response to DNA damage or disruptio -
Synonyms
RAD17;RAD17 homolog (S. pombe);RAD1 (S. pombe) homolog;cell cycle checkpoint protein RAD17;CCYC;RAD17Sp;Rad24;RAD1 homolog;Rad17-like protein;RF-C activator 1 homolog;RF-C/activator 1 homolog;cell cycle checkpoint protein (RAD17);R24L
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| RAD17-2152H | Recombinant Human RAD17, GST-tagged | E.coli | Human | GST | 431-681aa | |
| RAD17-2153H | Recombinant Human RAD17 Protein, His-tagged | E.coli | Human | His | 431-681aa | |
| RAD17-7137C | Recombinant Chicken RAD17 | Mammalian Cell | Chicken | His |
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| RAD17-771Z | Recombinant Zebrafish RAD17 | Mammalian Cell | Zebrafish | His |
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| RAD17-2562HCL | Recombinant Human RAD17 293 Cell Lysate | HEK293 | Human | Non |
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| RAD17-2563HCL | Recombinant Human RAD17 293 Cell Lysate | HEK293 | Human | Non |
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Involved Pathway
RAD17 involved in several pathways and played different roles in them. We selected most pathways RAD17 participated on our site, such as Activation of ATR in response to replication stress,Cell Cycle,Cell Cycle Checkpoints, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAD17 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| DNA damage response | GADD45G,GADD45A,CHEK2,TLK2,RAD9A,CDK5,DDB2,HUS1B,RAD1 |
| Cell cycle | CDK5RAP2,ENSAA,ACD,CEP72,MYBL2,ANAPC5,TFDP2,CDKN1BB,ODF2B,MSH5 |
| Activation of ATR in response to replication stress | CDK2,MCM10,CLSPN,RAD9B,RAD9A,RAD9,CHEK1,DBF4,RAD1,MCM8 |
| Gastric cancer network 2 | CEBPZ,LBR,CHTF8,PLAC8,MTDH,BRIX1,ATAD2,DSCC1,SNRPN,CHTF18 |
| DNA Repair | CHEK1,TIPIN,RAD9A,TOPBP1,DDB2,ASCC2,RNF111,PIAS3,COPS3,WRN |
| Cell Cycle Checkpoints | KAT5,YWHAQ,MCM8,DBF4,CDK5RAP2,RAD9B,RAD9,TP53BP1,RAD50,BRCC3 |
| G2/M Checkpoints | TP53BP1,HUS1,RAD9,THRSP,FAM175A,BABAM1,BARD1,RAD1,BRCC3,RNF168 |
| DNA Double-Strand Break Repair | HUS1,RBBP8,FUZ,UIMC1,TIMELESS,POLD3,PPP4CA,GEN1,CHEK2,EME1 |
Protein Function
RAD17 has several biochemical functions, for example, ATP binding,DNA clamp loader activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RAD17 itself. We selected most functions RAD17 had, and list some proteins which have the same functions with RAD17. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA clamp loader activity | RFC3 |
| protein binding | VIPAS39,ZBTB44,SIRPG,EPM2AIP1,HPSE,RCC2,PIM1,NBN,ZNF350,ZFP57 |
| ATP binding | ACVR2B,DCLK1,GSS,ACTB1,KIF5C,MAPK8,PANK1A,CUL9,OBSCN,TOR1L1 |
Interacting Protein
RAD17 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAD17 here. Most of them are supplied by our site. Hope this information will be useful for your research of RAD17.
NBN;MRE11A;RAD50;RAD9A;FZR1;USP20;PRMT6;npm_alk;CBX6;CBX7
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References
- Young, JL; Koon, EC; et al. Differential hRad17 expression by histologic subtype of ovarian cancer. JOURNAL OF OVARIAN RESEARCH 4:-(2011).
- Sukhanova, MV; D'Herin, C; et al. Interaction of Ddc1 and RPA with single-stranded/double-stranded DNA junctions in yeast whole cell extracts: Proteolytic degradation of the large subunit of replication protein A in ddc1 Delta strains. DNA REPAIR 22:30-40(2014).
