RAD1
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Official Full Name
RAD1 homolog -
Overview
This gene encodes a component of a heterotrimeric cell cycle checkpoint complex, known as the 9-1-1 complex, that is activated to stop cell cycle progression in response to DNA damage or incomplete DNA replication. The 9-1-1 complex is recruited by RAD17 to affected sites where it may attract specialized DNA polymerases and other DNA repair effectors. Alternatively spliced transcript variants of this gene have been described. -
Synonyms
RAD1;RAD1 homolog (S. pombe);RAD1 (S. pombe) homolog;cell cycle checkpoint protein RAD1;cell cycle checkpoint protein Hrad1;checkpoint control protein HRAD1;DNA repair exonuclease REC1;exonuclease homolog RAD1;HRAD1;Rad1 like DNA damage checkpoin
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Rhesus macaque
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- DDK
- Myc
- Avi
- Fc
Involved Pathway
RAD1 involved in several pathways and played different roles in them. We selected most pathways RAD1 participated on our site, such as Activation of ATR in response to replication stress,Cell Cycle,Cell Cycle Checkpoints, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell Cycle Checkpoints | RNF168,CLSPN,UIMC1,MCM8,CHEK1,BABAM1,YWHAQ,RAD50,RAD17,RAD9B |
| Cell cycle | MIS12,MCM6,CCNA2,CDC23,TGFB1,DMC1,AKAP9,CEP76,DHFR,CDC14B |
| DNA damage response | GADD45G,RAD17,TLK2,GADD45A,CHEK2,HUS1B,RAD9A,CDK5,DDB2 |
| DNA Repair | ASCC2,DDB2,ERCC8,TIMELESS,PPP4R2B,ALKBH3,CHD1L,RNF111,ZBTB32,UIMC1 |
| HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) | BRE,BRCC3,PPP4CA,RHNO1,PPP4R2,TIPIN,EME2,RBBP8,TOPBP1,RAD9 |
| G2/M Checkpoints | BRCC3,RAD9,UIMC1,FAM175A,THRSP,RAD17,BRE,BABAM1,RAD9B,BARD1 |
| DNA Double-Strand Break Repair | UBE2V2,WRN,RAD9A,TDP2,RAD51AP1,EYA3,BABAM1,SMARCA5,FUZ,BAZ1B |
| Activation of ATR in response to replication stress | RAD17,CDK2,HUS1,DBF4,CLSPN,MCM8,CHEK1,RAD9,MCM10,RAD9B |
Protein Function
RAD1 has several biochemical functions, for example, 3-5 exonuclease activity,damaged DNA binding,exodeoxyribonuclease III activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RAD1 itself. We selected most functions RAD1 had, and list some proteins which have the same functions with RAD1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| exodeoxyribonuclease III activity | RAD9A,TREX2,TREX1,RAD9 |
| damaged DNA binding | TP53,ERCC1,RAD23A,APTX,POLI,TP63,RBBP8,RPS3,XRCC5,BRCA1 |
| protein binding | AP3M1,AGTRAP,LHX9,ADAT2,COMMD5,KRT1,ANKS1A,JAG1,EP300,ABCG1 |
| 3-5 exonuclease activity | POLA1,EXD1,MRE11A,ERI1,APLF,RAD9A,RAD9,EXD2,REV3L,REXO2 |
Interacting Protein
RAD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RAD1.
HUS1;RAD9A;PARK2;MAP1LC3B
Resources
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References
- Saberi, A; Nakahara, M; et al. The 9-1-1 DNA clamp is required for immunoglobulin gene conversion. MOLECULAR AND CELLULAR BIOLOGY 28:6113-6122(2008).
- Bozdarov, J; Sherry, JP; et al. The rad1 gene in Rainbow Trout (Oncorhynchus mykiss) is highly conserved and may express proteins from non-canonical spliced isoforms. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY 157:16-23(2013).
