RACGAP1
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Official Full Name
Rac GTPase activating protein 1 -
Overview
The protein encoded by this gene belongs to the GTPase-activating protein (GAP) family. GAPs bind activated forms of Rho GTPases and stimulate GTP hydrolysis. Through this catalytic function, GAPs negatively regulate Rho-mediated signals. This protein plays a regulatory role in initiation of cytokinesis, controlling cell growth and differentiation of hematopoietic cells, regulating spermatogenesis, and in neuronal proliferation. Alternatively spliced transcript variants have been found for this gene. -
Synonyms
RACGAP1;Rac GTPase activating protein 1;rac GTPase-activating protein 1;MgcRacGAP;protein CYK4 homolg;male germ cell RacGap;GTPase activating protein;CYK4;ID-GAP;HsCYK-4
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Rhesus macaque
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- DDK
- Myc
- Avi
- Fc
Involved Pathway
RACGAP1 involved in several pathways and played different roles in them. We selected most pathways RACGAP1 participated on our site, such as Adaptive Immune System,Aurora B signaling,Factors involved in megakaryocyte development and platelet production, which may be useful for your reference. Also, other proteins which involved in the same pathway with RACGAP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Immune System | RNF14,RNF123,SIGLEC12,KIF2C,CFHL3,SAMHD1,ACTR1B,DEFB125,GBP1,ARIH1L |
| RAC1 signaling pathway | ABI2,NOXO1,NCKAP1,BAIAP2,NOXA1,IQGAP3,ABI1 |
| Hemostasis | SH2B3,HMG20B,TRPC7,TRPC6A,STXBP3,SLC8A2A,DOCK7,SERPINE2,CFHL4,SIRPA |
| Aurora B signaling | NDC80,NCAPH,KIF20A,CBX5,NSUN2,SGOL1,KIF2C,NPM1,CENPA,AURKC |
| Factors involved in megakaryocyte development and platelet production | ZFPM2A,KIF11,KIF9,AKAP1B,ZFPM1,DOCK10,LRRC16A,KIF3A,DOCK1,KIF2C |
| Kinesins | KIF2A,KIF9,KIF4,KIF3C,KIF3B,KIFAP3,KIF15,KIF2B,KLC3,KIF26A |
| Adaptive Immune System | SIGLEC10,ASB11,KIF22,CRTAM,KIFAP3,TRAF7,KIF2A,CD200,FCGR1B,RBCK1 |
| MHC class II antigen presentation | DYNC1LI2,MGC174152,OSBPL1A,KIF22,KIF26A,DCTN6,ACTR1B,CTSLL,FAM49BA,CTSC |
Protein Function
RACGAP1 has several biochemical functions, for example, GTPase activator activity,alpha-tubulin binding,beta-tubulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RACGAP1 itself. We selected most functions RACGAP1 had, and list some proteins which have the same functions with RACGAP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | SMAGP,CSDE1,KIAA0101,PRNP,SPRY4,SGCA,PA2G4,SNRPD1,RAB7A,VARS2 |
| phosphatidylinositol-3,4,5-trisphosphate binding | ANXA8,ZFYVE16,PHLDA3,INPPL1,ARAP2,KIF16B,DAPP1,COMMD1,ARAP1,PIRT |
| protein kinase binding | EMP2,PTPRJ,CCNK,TTN,PRDX3,CENPJ,SMAD1,LSM2,TCF7L2,RAB11FIP2 |
| beta-tubulin binding | ARL8B,SERPINB1A,NDEL1,EMD,SPAST,PROL1,ADNP,TRPV4,ARL8A,GABARAP |
| microtubule binding | KIF4A,MTAP7D3,CHD4,S100A9,DPYSL5,DPYSL5B,KIAA1128,KIF22,GAS2L1,KIFC3 |
| metal ion binding | NT5C,PRKD2,ZC3H3,RPAIN,ZNF567,METAP2A,LMAN1,ZFP518A,UBE3A,EXOG |
| gamma-tubulin binding | B9D2,TUBGCP3,TUBGCP4,BRCA2,BLOC1S2,OFD1,PIFO,WASH,MARK4,RAB11FIP5 |
| GTPase activator activity | LRRK2,RP2,RIC8,RAP1GAP2B,ACAP3,ASAP3,DAB2IPB,RABEP1,RGS9A,ARHGEF15 |
| alpha-tubulin binding | C9orf24,PROL1,CAV3,WASH1,ARL8B,NDEL1,DDL-2,HDAC6,TRPV4,FAM110C |
Interacting Protein
RACGAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RACGAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RACGAP1.
KIF23;YWHAG;RAB11FIP3
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