Rab27a
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Official Full Name
RAB27A, member RAS oncogene family -
Overview
The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Mutations in this gene are associated with Griscelli syndrome type 2. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. -
Synonyms
RAB27A;RAB27A, member RAS oncogene family;ras-related protein Rab-27A;GS2;HsT18676;RAB27;RAM;rab-27;GTP-binding protein Ram;MGC117246
Recombinant Proteins
- Rat
- Human
- Zebrafish
- Rhesus macaque
- Chicken
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- Non
- GST
- His
- DDK
- Myc
- Avi
- Fc
Involved Pathway
Rab27a involved in several pathways and played different roles in them. We selected most pathways Rab27a participated on our site, such as Deregulation of Rab and Rab Effector Genes in Bladder Cancer,Insulin processing,Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with Rab27a were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism of proteins | TUBA3D,ALG10B,SAMM50,SEC23IP,TIMM23,PREB,ALG2,TOMM40,INHBAA,PPP6C |
| Peptide hormone metabolism | CGB7,SPCS3,PCSK2,GZMH,CPN1,CDX2,SLC30A6,CMA1,ATP6AP2,GRP |
| Insulin processing | CPE,PCSK1,PCSK2,SLC30A8,EXOC8,EXOC6,KIF5A,EXOC1,SLC30A6,KIF5B |
| Deregulation of Rab and Rab Effector Genes in Bladder Cancer | UNC13D,MYRIP,RPH3AL,RPH3A,GCC2,MLPH,TBC1D10A,SYTL1,SYTL3,SYTL4 |
Protein Function
Rab27a has several biochemical functions, for example, GDP binding,GTP binding,GTPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Rab27a itself. We selected most functions Rab27a had, and list some proteins which have the same functions with Rab27a. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | WDR74,PIM1,CBR2,SCG5,HBXIP,ADORA1,NEURL1B,VHL,PCNA,UBB |
| GTP binding | RAB42A,GTPBP5,TUBA8L,LRRK2,RHOBTB2A,RND1L,MTIF2,RAB1B,RAP2C,RAB7 |
| myosin V binding | RAB3D,RAB39B,RAB3C,RAB25,RAB3B,RAB8A,RAB11A,RAB10,RAB6B,RAB27B |
| protein domain specific binding | STAMBP,AIDA,DYNLL1,IL1B,DBNL,TH,FOXA3,TNNI3,MPP7,OSBP |
| GTPase activity | GBP6,EEF1A1A,EFTUD2,RRAGD,TUBA8L2,GBP4,RAB15,MXC,GNA13B,MSTO1 |
| GDP binding | RAB4A,RALB,RAB9A,RAB8B,ARL2,SRP54A,RAB27B,ARL8B,RAP1B,RRAS |
Interacting Protein
Rab27a has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Rab27a here. Most of them are supplied by our site. Hope this information will be useful for your research of Rab27a.
MLPH;ACTA1;GDF9;EEF1A1;ZBTB16;RBM48;RIF1;COPS6;cpsG;CEP126;C14orf1
Resources
Research Area
Lysosomal EnzymesPhospholipases, Small GTPases, and Other Molecules in the Akt Pathway
Rab Proteins
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References
- Nagashima, S; Jirintai, S; et al. Hepatitis E virus egress depends on the exosomal pathway, with secretory exosomes derived from multivesicular bodies. JOURNAL OF GENERAL VIROLOGY 95:2166-2175(2014).
- Bustos, MA; Lucchesi, O; et al. Rab27 and Rab3 sequentially regulate human sperm dense-core granule exocytosis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 109:E2057-E2066(2012).
