PYGL
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Official Full Name
phosphorylase, glycogen, liver -
Overview
This gene encodes a homodimeric protein that catalyses the cleavage of alpha-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. This protein switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 15. Activity of this enzyme is further regulated by multiple allosteric effectors and hormonal controls. Humans have three glycogen phosphorylase genes that encode distinct isozymes that are primarily expressed in liver, brain and muscle, respectively. The liver isozyme serves the glycemic demands of the body in general while the brain and muscle isozymes supply just those tissues. In glycogen storage disease type VI, also known as Hers disease, mutations in liver glycogen phosphorylase inhibit the conversion of glycogen to glucose and results in moderate hypoglycemia, mild ketosis, growth retardation and hepatomegaly. Alternative splicing results in multiple transcript variants encoding different isoforms. -
Synonyms
PYGL;phosphorylase, glycogen, liver;phosphorylase, glycogen;liver;glycogen phosphorylase, liver form;glycogen storage disease type VI;Hers disease;GSD6
Recombinant Proteins
- Zebrafish
- Human
- Rat
- Chicken
- Mouse
- Mammalian Cells
- Wheat Germ
- E.coli
- Yeast
- HEK293
- In Vitro Cell Free System
- His
- Non
- Flag
- His&Fc&Avi
- Myc&DDK
- GST
Involved Pathway
PYGL involved in several pathways and played different roles in them. We selected most pathways PYGL participated on our site, such as Starch and sucrose metabolism,Metabolic pathways,Insulin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PYGL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Starch and sucrose metabolism | UGP2A,AMY2A3,ENPP1,UGT1A6,UGT5G1,SI,AMY2A5,UGT2B15,UGT1A4,AMY2A4 |
| Insulin resistance | PRKCBB,PTPN11,PDPK1B,NFKBIAB,SREBF1,MLXIPL,RPS6KA2,PIK3R5,PRKAA2,INSRB |
| Metabolic pathways | INPP4B,UGDH,NME2B.2,AK9,PFKMA,FDFT1,LDHA,EXTL2,AKR1B1L,DTYMK |
| Insulin signaling pathway | PRKAR1AB,TSC1A,PCK2,CALML5,PHKG1B,PYGMA,RPS6KB1B,SLC2A4,PRKACBA,PIK3CD |
Protein Function
PYGL has several biochemical functions, for example, AMP binding,ATP binding,bile acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PYGL itself. We selected most functions PYGL had, and list some proteins which have the same functions with PYGL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| AMP binding | PYGM,APRT,PRKAG1,PRPS1,PRPS2,CYB5R3,FBP1,ACSS1,PRKAG2,ACSS2 |
| glucose binding | HK1,SLC2A3,SLC2A8,G6PD,GYS1,HK2,HKDC1,G6PDX,UGP2,HK3 |
| protein homodimerization activity | ZFP365,S100B,ERCC5,ANXA6,DLK2,C6orf108,ANO6,CEP57,CDSN,SEPT12 |
| bile acid binding | STARD5,NR1H4,FABP10A,FABP1,PLA2G1B,AKR1C2,FABP6,AKR1C21 |
| glycogen phosphorylase activity | PYGB,PYGMA,PYGMB,PYGM |
| pyridoxal phosphate binding | PDXDC2P,AGXT2L1,CBSA,CTHL,ETNPPL,MOCOS,GOT2,KYNU,GOT2A,SPTLC2 |
| purine nucleobase binding | PNP |
| protein binding | SRGN,SPATA22,DYNC1I2,RBM8A,DOK6,LOR,TGFBR2,RNF146,RBM5,TPI1 |
| ATP binding | CARKD,BMPR1AA,ABCA6,TDRD12,CDC34,ERBB3B,ACSBG2,GRK4,LATS2,CCT8L2 |
Interacting Protein
PYGL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PYGL here. Most of them are supplied by our site. Hope this information will be useful for your research of PYGL.
PYGB;USP19;IDH2;BAG1;HSD3B7;IKBKB;GABARAPL2;FKBP5;Ripk3
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References
- Liu, J; Wang, X; et al. Maslinic acid modulates glycogen metabolism by enhancing the insulin signaling pathway and inhibiting glycogen phosphorylase. CHINESE JOURNAL OF NATURAL MEDICINES 12:259-265(2014).
- Zhou, DX; Zheng, LY; et al. Identification and differential expression of human carcinoma-associated antigens in hepatocellular carcinoma tissues. EXPERIMENTAL BIOLOGY AND MEDICINE 238:167-175(2013).
