PVRL3
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Official Full Name
poliovirus receptor-related 3 -
Overview
Nectins originally identified as poliovirus receptor-related protein (PRR) are Ca2+-independent immunoglobulin-like cell-cell-adhesion molecules. Nectins comprise a family of four members: nectin-1 (CD111/PRR1), nectin-2 (CD112/PRR2), nectin-3 (CD113/PRR3 -
Synonyms
PVRL3;poliovirus receptor-related 3;poliovirus receptor-related protein 3;CD113;CDw113;DKFZP566B0846;nectin 3;PPR3;PVRR3;PRR3;NECTIN-3;FLJ90624
Recombinant Proteins
- Human
- Mouse
- HEK293
- Mammalian cells
- E.coli
- Human Cell
- His
- His&T7
- Non
- Fc
- Fc&Avi
- His&Fc
- His&Fc&Avi
Involved Pathway
PVRL3 involved in several pathways and played different roles in them. We selected most pathways PVRL3 participated on our site, such as Cell adhesion molecules (CAMs),Adherens junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with PVRL3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adherens junction | ACTG1,NLK2,SNAI2,CDH1,PVRL1,ACTN1,PTPN1,YES1,EP300,IGF1R |
| Cell adhesion molecules (CAMs) | CLDN10A,CDH3,NCAM1,CLDN9,CNTNAP1,MHC2DAB,CLDN11A,VCAM1,HLA-A,MPZL1L |
Protein Function
PVRL3 has several biochemical functions, for example, cell adhesion molecule binding,protein binding,protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PVRL3 itself. We selected most functions PVRL3 had, and list some proteins which have the same functions with PVRL3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cell adhesion molecule binding | NRXN1,JUP,NLGN2,POSTN,ITGB3,SDCBP,CADM4,MSN,PVRL2L,CDH1 |
| protein homodimerization activity | CHMP3,AGR2,MYOM1,MTPAP,TCF3,EVLA,GTF2A2,NCR3,TPD52L1,ASNSD1 |
| protein binding | PSMB1,PDIA4,TMEM115,MKRN1,CHID1,CRCT1,GTF3C5,PAWR,SUCLA2,AGFG1 |
| receptor binding | NMU,PTK2AB,CCL15,CXCL10,SLC9A3R2,WNT7AA,CYTL1,LEPROT,IDE,RARRES2 |
| receptor activity | IGSF1,GRIN1A,PAQR9,GRIN2A,NOTCH1A,MED4,TNFRSF6B,BTN1A1,GABRA5,MRC1 |
Interacting Protein
PVRL3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PVRL3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PVRL3.
MLLT4;PVRL2;PVRL1;RGS20;KRTAP10-7;KRTAP10-8
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References
- Pang, J; Borjeson, TM; et al. Megaesophagus in a Line of Transgenic Rats: A Model of Achalasia. VETERINARY PATHOLOGY 51:1187-1200(2014).
- Lachke, SA; Higgins, AW; et al. The cell adhesion gene PVRL3 is associated with congenital ocular defects. HUMAN GENETICS 131:235-250(2012).
