PTPRK

  • Official Full Name

    protein tyrosine phosphatase, receptor type, K

  • Overview

    The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation.

  • Synonyms

    PTPRK;protein tyrosine phosphatase, receptor type, K;receptor-type tyrosine-protein phosphatase kappa;R PTP kappa;dJ480J14.2.1;DKFZp686C2268;DKFZp779N1045;OTTHUMP00000017180;OTTHUMP00000017181;OTTHUMP00000017182;OTTHUMP00000017187;OTTHUMP00000040306;Protein tyrosine phosphatase kappa;Protein tyrosine phosphatase kappa precursor;Protein tyrosine phosphatase receptor type K;Protein tyrosine phosphatase receptor type kappa;Protein-tyrosine phosphatase kappa;PTPK;PTPkappa;PTPRK_HUMAN;R-PTP-kappa;Receptor type tyrosine protein phosphatase kappa;OTTHUMP00000233054;OTTHUMP00000233055;OTTHUMP00000233080;protein-tyrosine phosphatase, receptor type, kappa;dJ480J14.2.1 (protein tyrosine phosphatase, receptor type, K (R-PTP-KAPPA, protein tyrosine phosphatase kappa , protein tyrosine phosphatase kappa

Recombinant Proteins

  • Mouse
  • Human
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • T7
  • Flag
  • Avi
  • Fc
  • DDK
  • Myc

    Involved Pathway

    PTPRK involved in several pathways and played different roles in them. We selected most pathways PTPRK participated on our site, such as EGFR downregulation,Signal Transduction,Signaling by EGFR, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTPRK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    EGFR downregulation STAM2,AP2S1,SPRY1,SPRY2,AP2M1,AP2B1,AP2A2,AP2A1
    Signaling by EGFR LRIG1,PAG1,ADAM12,SPRY1
    Signal Transduction BBS13,RGS6,DEPDC7,SPOPL,GHRB,AMOTL2B,TAX1BP3,RGS10,RGS17,DHRS3A

    Protein Function

    PTPRK has several biochemical functions, for example, beta-catenin binding,gamma-catenin binding,hydrolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PTPRK itself. We selected most functions PTPRK had, and list some proteins which have the same functions with PTPRK. You can find most of the proteins on our site.

    Function Related Protein
    phosphoprotein phosphatase activity PPP3CB,DUSP10,PTPN11B,DUSP28,PPP3CCB,PPP4CB,PPAP2B,CDC25D,PTPN2B,PTPRU
    phosphatase activity MINPP1B,SACM1LA,ACPL2,TIGARB,CTDSPLB,DUSP23A,CTDNEP1,DUSP28,PTPRNA,PTPRFB
    hydrolase activity CTSL1B,USP9,CPSF5,ENOPH1,PNPLA5,TDRD9,EIF4A1B,Adamts19,ATAD1B,CASP3A
    protein tyrosine phosphatase activity DUSP23B,MTMR8,MTMR3,DUSP19B,MTMR4,CDC14B,DUSP6,PTPRNA,PTPDC1,DUSP18
    gamma-catenin binding APC2,APC,CTNNA1,CDH2,TCF7L2,CDH1,DSG1,DSG1A,FER,PTPRJ
    beta-catenin binding MED12,BCL9L,BCL9,CXADR,ESR1,C,CDH2,PTBP3,CBY1,CARM1
    protein kinase binding TP53,NIPAL1,XBP1,MAP3K5,KIF11,DAXX,SMAD1,EPHA1,CALM,CDKN2C

    Interacting Protein

    PTPRK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTPRK here. Most of them are supplied by our site. Hope this information will be useful for your research of PTPRK.

    Ywhae

    Resources

    Gene Families

    What is immunoglobulin superfamily (IgSF)

    References

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