PTGS2
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Official Full Name
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -
Overview
Cytochrome c oxidase subunit II, also known as COX2, is a human protein and gene. that belongs to cytochrome c oxidase subunit II protein family. It is sometimes confused with the cyclooxygenase enzyme COX-2. -
Synonyms
Ptgs2;prostaglandin-endoperoxide synthase 2;COX2;Cox-2;PHS-2;Pghs2;TIS10;PGHS-2;PES-2;PHS II;gripghs;PGH synthase 2;cyclooxygenase 2;cyclooxygenase-2;prostaglandin H2 synthase 2;glucocorticoid-regulated inflammatory cyclooxygenase;macrophage activation-associated marker protein P71/73;prostaglandin G/H synthase, Tis10
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rat
- Sheep
- Insect Cells
- Insect cells
- Mammalian Cells
- Sf21 Cells
- E.coli
- HEK293
- Sheep placenta
- His
- Flag&His
- Non
- His&T7
- Avi&Fc&His
Involved Pathway
PTGS2 involved in several pathways and played different roles in them. We selected most pathways PTGS2 participated on our site, such as Arachidonic acid metabolism,Metabolic pathways,NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTGS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chemical carcinogenesis | GSTK1,SULT1A3,NAT2,CYP2B19,AHA-1,GSTM6,GSTT1,GSTA5,CYP1A1,ADH7 |
| Pathways in cancer | STAT5B,LAMC2,CBLB,FLT3,MAX,TGFB1,GNG2,NCOA4,SLC2A1,LPAR6 |
| NF-kappa B signaling pathway | BCL10,PLCG1,Ccl21c,CARD11,CD14,IL-8,NFKBIA,CXCL2,IRAK4,CCL21B |
| Small cell lung cancer | CCNE1,TRAF1,ITGA2,PTK2,BCL2L1,XIAP,PIK3R1,IKBKG,ITGA6,RXRG |
| VEGF signaling pathway | HRASA,RAC2,PRKCBB,SH2D2A,PPP3R2,RAF1,HRASB,VEGFAA,VEGFA,MAPK1 |
| Ovarian steroidogenesis | PLA2G4A,LHB,CYP2J6,GNAS,PRKACA,PLA2G4C,HSD3B6,ACOT2,BMP15,INSR |
| Arachidonic acid metabolism | ALOX8,GGT1A,FAAH2,PTGES,CYP2C39,CYP1B1,CYP2P7,CYP2C50,PLA2G4B,CYP2C19 |
| Retrograde endocannabinoid signaling | GNAO1,MAPK3,GRM5,MAPK10,GNG11,ABHD6,GNG5,GRIA2,MAPK13,GABRE |
| Serotonergic synapse | APP,HTR6,HTR1F,PLA2G4F,ALOX15B,CYP2C55,PRKACB,NRAS,TPH2,HTR5A |
Protein Function
PTGS2 has several biochemical functions, for example, dioxygenase activity,heme binding,lipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTGS2 itself. We selected most functions PTGS2 had, and list some proteins which have the same functions with PTGS2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| lipid binding | FABP11A,MARK2,BPIFB7,UNC119B,PITPNC1,CYTH1,S100A13,ACOT11A,AP2M1A,ALOX8 |
| heme binding | JAK2,CYB5A,CYP7A1A,HBA-A2,CYP2F1,CYP2X9,CYP2A12,CYP2K18,CYP2K17,SRC |
| prostaglandin-endoperoxide synthase activity | PTGS1,PTGS2A,PTGS2B |
| dioxygenase activity | HPDB,KDM4B,MINA,P4HA1B,ASPHD1,ASPHD2,OGFOD2,KDM5BB,KDM6A,ALOX5B.2 |
| metal ion binding | SETDB1A,ESRRGB,ZSCAN20,ITGB1BP3,OAS2,CHPF,MARCH5L,ZBTB3,PRDM12B,ZNF609A |
| peroxidase activity | MGST3,PTGS2B,TPO,PTGS2A,GPX8,GPX1B,IPCEF1,GPX4A,CYGB,GPX1A |
Interacting Protein
PTGS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTGS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTGS2.
arachidonic acid;ns398;q9wmx2-pro_0000037550;LRRK2
Resources
Research Area
Cancer Drug TargetsNeuroinflammation
MDSC Intracellular Signaling Factors
Gastric Cancer Biomarkers
Related Services
Related Products
References
- Addison, JB; Koontz, C; et al. KAP1 Promotes Proliferation and Metastatic Progression of Breast Cancer Cells. CANCER RESEARCH 75:344-355(2015).
- Jang, YJ; Park, JI; et al. Cumulus Cell-Expressed Type I Interferons Induce Cumulus Expansion in Mice. BIOLOGY OF REPRODUCTION 92:-(2015).
