PTGS1
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Official Full Name
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) -
Overview
This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] -
Synonyms
PTGS1;prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase);COX1;COX3;PHS1;PCOX1;PES-1;PGHS1;PTGHS;PGG/HS;PGHS-1;prostaglandin G/H synthase 1;PGH synthase 1;cyclooxygenase-1;prostaglandin H2 synthase 1
Recombinant Proteins
- Mouse
- Rat
- Human
- Zebrafish
- Sheep
- Mammalian Cells
- E.coli
- HEK293
- Insect Cells
- Ram Seminal Vesicles
- Ram seminal vesicles
- His
- T7
- Non
- Avi
- Fc
- DDK
- Myc
- Flag
Involved Pathway
PTGS1 involved in several pathways and played different roles in them. We selected most pathways PTGS1 participated on our site, such as Arachidonic acid metabolism,Metabolic pathways,Platelet activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTGS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | MAT2AA,NAT8L,UCK1,INPP5J,RABGNT1,PLD3,HIBCH,PIGX,ST3GAL1,ITGB1BP3 |
| Serotonergic synapse | GNB3,PLCB4,HTR1B,GABRB1,HTR3A,GNG8,TPH1,MAPK1,GNAQ,GNAI2 |
| Regulation of lipolysis in adipocytes | Adcy4,PLIN1,NPY,NPY1R,PIK3CG,PIK3R2,LOC100328615,PRKACB,INS1,FABP4 |
| Arachidonic acid metabolism | CYP2AD6,CYP2C55,PTGDSA,CYP2C37,ALOX15,PTGS2B,CYP2J2,PTGES3A,PTGS2,PTGDSB |
| Platelet activation | ARHGEF12,PIK3R3,ARHGEF1,APBB1IP,VWF,MYLK4,GNAI2,VAMP8,GUCY1B3,AKT2 |
Protein Function
PTGS1 has several biochemical functions, for example, dioxygenase activity,heme binding,lipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTGS1 itself. We selected most functions PTGS1 had, and list some proteins which have the same functions with PTGS1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| prostaglandin-endoperoxide synthase activity | PTGS2,PTGS2B,PTGS2A |
| metal ion binding | GFI1AB,DNAJC21,CA,ZBTB2A,ZNF438,TNNI3K,ROCK2,MPO,ZNF124,ZFP41 |
| dioxygenase activity | P4HA1B,ADOA,KDM5D,ASPHD1,ASPHD2,KDM4D,ALKBH7,OGFOD2,PHF2,OGFOD3 |
| peroxidase activity | DUOX2,MGST3,EPX,CYGB,GPX4B,GPX7,PXDN,PTGS2,PRDX5,GPX8 |
| lipid binding | FABP5,CRABP2A,COQ9,BPIFB7,UNC119.1,PITPNM2,ACOT11A,RASGRP2,APOA1B,FER |
| heme binding | CYP4X1,HBBE2,CYP2A7,CYP46A1.2,CYP2D6,HBB-B2,CYP4A11,CYP3C1,NOS3,CYP26A1 |
Interacting Protein
PTGS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTGS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTGS1.
Dlg4;arachidonic acid;diclofenac
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