PSMF1
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Official Full Name
proteasome (prosome, macropain) inhibitor subunit 1 (PI31) -
Overview
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a protein that inhibits the activation of the proteasome by the 11S and 19S regulators. Alternative transcript variants have been identified for this gene. -
Synonyms
PSMF1;proteasome (prosome, macropain) inhibitor subunit 1 (PI31);proteasome inhibitor PI31 subunit;PI31;proteasome inhibitor hP131 subunit;hPI31
Recombinant Proteins
- Human
- Chicken
- Rat
- Zebrafish
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- Flag
- His&Fc&Avi
- Myc&DDK
- His&SUMO
Involved Pathway
PSMF1 involved in several pathways and played different roles in them. We selected most pathways PSMF1 participated on our site, such as Proteasome, which may be useful for your reference. Also, other proteins which involved in the same pathway with PSMF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Proteasome | PSMC5,PSMB5,PSMB2,PSMA3,PSMB6,PSMD2,PSMD4B,PSMA7,PSMB10,PSMA6A |
Protein Function
PSMF1 has several biochemical functions, for example, endopeptidase inhibitor activity,proteasome binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PSMF1 itself. We selected most functions PSMF1 had, and list some proteins which have the same functions with PSMF1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| endopeptidase inhibitor activity | Cstb,PCSK1N,C4A,A1i3,PZP,USP14,UCHL5,SPINK1,CST3,SERPINA1D |
| proteasome binding | UCHL5,USP13,PSMG1,BAG6,USP14,DNAJB2,ID1,ADRM1,PSMD14,UBD |
| protein binding | DDR1,HIST1H4H,ACP1,HAPLN2,ACACB,CSF2RB,XK,RPS6KA5,DCLRE1C,LTA4H |
Interacting Protein
PSMF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PSMF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PSMF1.
FBXO7;CD2BP2;RBFOX1;RBFOX2;LDOC1;tax;BEND7;PAK7;PSMA7;KHDRBS3
Resources
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References
- Li, XH; Thompson, D; et al. Molecular and Cellular Roles of PI31 (PSMF1) Protein in Regulation of Proteasome Function. JOURNAL OF BIOLOGICAL CHEMISTRY 289:17392-17405(2014).
- Hatanaka, A; Chen, B; et al. Fub1p, a novel protein isolated by boundary screening, binds the proteasome complex. GENES & GENETIC SYSTEMS 86:305-314(2011).
