PSMD8
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Official Full Name
proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 -
Overview
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway.An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 1. -
Synonyms
PSMD8;proteasome (prosome, macropain) 26S subunit, non-ATPase, 8;26S proteasome non-ATPase regulatory subunit 8;HIP6;HYPF;Nin1p;p31;Rpn12;S14;26S proteasome non ATPase regulatory subunit 8;26S proteasome regulatory subunit p31;26S proteasome regulatory subunit RPN12;26S proteasome regulatory subunit S14;AAV38494;MGC1660;Proteasome (prosome macropain) 26S subunit non ATPase 8;PSMD8_HUMAN;OTTHUMP00000198258
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PSMD8-30431TH | Recombinant Human PSMD8 | Wheat Germ | Human | Non | 257 amino acids |
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| PSMD8-358Z | Recombinant Zebrafish PSMD8 | Mammalian Cell | Zebrafish | His |
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| PSMD8-2744HCL | Recombinant Human PSMD8 293 Cell Lysate | HEK293 | Human | Non |
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| PSMD8-2636H | Recombinant Human PSMD8 Protein, His-tagged | E.coli | Human | His | Met1-Val350 |
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| Psmd8-5199M | Recombinant Mouse Psmd8 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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Involved Pathway
PSMD8 involved in several pathways and played different roles in them. We selected most pathways PSMD8 participated on our site, such as Proteasome,Epstein-Barr virus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with PSMD8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Epstein-Barr virus infection | RBPJL,CR2,HDAC5,HLA-DRA,PSMD2,HLA-F,EP300,FCER2,SHFM1,EIF2AK2 |
| Proteasome | PSMB11,PSMA5,PSMB7,PSMA6,PSMB1,PSMF1,PSMC3,PSMA6A,PSMD4,PSMC4 |
Protein Function
PSMD8 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by PSMD8 itself. We selected most functions PSMD8 had, and list some proteins which have the same functions with PSMD8. You can find most of the proteins on our site.
| Function | Related Protein |
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Interacting Protein
PSMD8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PSMD8 here. Most of them are supplied by our site. Hope this information will be useful for your research of PSMD8.
UCHL5;PSMD14;MCC;PSMD7;USP14;PSMD4;ARF6;PSMD6;PAAF1;PSMD13;TRAF6;SMAD9;SMAD2;Psmd14;PSMC1;ADRM1
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