PSMD1
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Official Full Name
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 -
Overview
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes the largest non-ATPase subunit of the 19S regulator lid, which is responsible for substrate recognition and binding. Alternatively spliced transcript variants have been found for this gene. -
Synonyms
PSMD1;proteasome (prosome, macropain) 26S subunit, non-ATPase, 1;26S proteasome non-ATPase regulatory subunit 1;P112;Rpn2;S1;MGC133041;26S proteasome non ATPase regulatory subunit 1;26S proteasome non ATPase subunit 1;26S proteasome regulatory subunit RPN2;26S proteasome regulatory subunit S1;26S proteasome subunit p112;MGC133040;Proteasome (prosome macropain) 26S subunit, non ATPase 1;PSMD1_HUMAN;OTTHUMP00000164295;OTTHUMP00000204737
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Chicken
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- GST
- His
- Non
- His&Fc&Avi
Involved Pathway
PSMD1 involved in several pathways and played different roles in them. We selected most pathways PSMD1 participated on our site, such as Proteasome,Epstein-Barr virus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with PSMD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Proteasome | PSMD4B,PSME4B,PSMB7,PSMA6,PSMC6,PSMD2,PSMD4A,PSMB9B,PSME4,PSMC5 |
| Epstein-Barr virus infection | SFPI1,HLA-DQB1,HLA-DRA,PLCG2,RIPK1,IKBKB,NFKBIA,HDAC4,GTF2E2,TBP |
Protein Function
PSMD1 has several biochemical functions, for example, contributes_to endopeptidase activity,enzyme regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PSMD1 itself. We selected most functions PSMD1 had, and list some proteins which have the same functions with PSMD1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to endopeptidase activity | PSMD2 |
| enzyme regulator activity | RAB3GAP2,RGN,CPN2,GCLM,PPP1R7,EIF2B1,PSMD3,DCP1B,DPM2,APOC3 |
Interacting Protein
PSMD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PSMD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PSMD1.
PSMC5;PSMD14;PSMD10;PSMC1;UCHL5;ESR2
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