PSMA5
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Official Full Name
proteasome (prosome, macropain) subunit, alpha type, 5 -
Overview
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010] -
Synonyms
PSMA5;proteasome (prosome, macropain) subunit, alpha type, 5;PSC5;ZETA;proteasome subunit alpha type-5;macropain zeta chain;proteasome zeta chain;macropain subunit zeta;proteasome component 5;proteasome subunit zeta;proteasome alpha 5 subunit;multicatalytic endopeptidase complex zeta chain
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Rhesus macaque
- Rat
- Mouse
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
PSMA5 involved in several pathways and played different roles in them. We selected most pathways PSMA5 participated on our site, such as Proteasome, which may be useful for your reference. Also, other proteins which involved in the same pathway with PSMA5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Proteasome | PSMD3,PSME4B,PSMD8,PSMD12,PSMB1,POMP,PSMD2,PSMB3,PSMD6,PSMA7 |
Protein Function
PSMA5 has several biochemical functions, for example, endopeptidase activity,protein binding,threonine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PSMA5 itself. We selected most functions PSMA5 had, and list some proteins which have the same functions with PSMA5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | MCCC1,KCNS2,MAP2K2,TBL3,WTIP,Serpina1b,TUBGCP3,LRGUK,BCKDK,NRSN1 |
| threonine-type endopeptidase activity | PSMB2,PSMB11,PSMA6A,PSMA7,PSMA3,PSMB9,PSMB5,PSMA8,PSMB1,PSMB8 |
| endopeptidase activity | CD46,TMEM59,PSMA3,PARL,Ren1,APH1C,KLK1B4,MMP1,TRAPPC12,TPP1 |
Interacting Protein
PSMA5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PSMA5 here. Most of them are supplied by our site. Hope this information will be useful for your research of PSMA5.
PSMA7;PSMA1;VCAM1;UCHL5;XBP1;NFKBIE;PSMA4;PSMD4;MESDC2;q7cj39_yerpe;ere_dna;PSMD14;GAK
Resources
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References
- Livinskaya, VA; Barlev, NA; et al. Immunoaffinity purification of the functional 20S proteasome from human cells via transient overexpression of specific proteasome subunits. PROTEIN EXPRESSION AND PURIFICATION 97:37-43(2014).
- Wu, JC; Chen, CH; et al. Electrophoresis-Enhanced Detection of Deoxyribonucleic Acids on a Membrane-Based Lateral Flow Strip Using Avian Influenza H5 Genetic Sequence as the Model. SENSORS 14:4399-4415(2014).
