PSMA4
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Official Full Name
proteasome (prosome, macropain) subunit, alpha type, 4 -
Overview
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
PSMA4;proteasome (prosome, macropain) subunit, alpha type, 4;proteasome subunit alpha type-4;HC9;HsT17706;Macropain subunit C9;MGC111191;MGC12467;MGC24813;Multicatalytic endopeptidase complex subunit C9;Proteasome (prosome macropain) subunit alpha type 4;Proteasome alpha 4 subunit;Proteasome component C9;Proteasome subunit alpha type 4;Proteasome subunit HC9;Proteasome subunit L;PSA4_HUMAN;PSC9;PSMA 4;OTTHUMP00000185020
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Rhesus macaque
- Chicken
- Rat
- Cynomolgus
- Staphylococcus aureus
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
PSMA4 involved in several pathways and played different roles in them. We selected most pathways PSMA4 participated on our site, such as Proteasome, which may be useful for your reference. Also, other proteins which involved in the same pathway with PSMA4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Proteasome | PSMB6,PSMD4A,PSMB11B,PSMA3,SHFM1,PSMD8,PSMA6A,PSMA6,PSMC4,PSMB9A |
Protein Function
PSMA4 has several biochemical functions, for example, endopeptidase activity,protein binding,threonine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PSMA4 itself. We selected most functions PSMA4 had, and list some proteins which have the same functions with PSMA4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| threonine-type endopeptidase activity | PSMB3,PSMA7,TASP1,PSMB4,PSMA5,PSMA6B,PSMB7,PSMB9,PSMB1,PSMB5 |
| protein binding | SPINK7,BAP1,HSPE1,TRIM10,CTLA2B,DSC2,CNOT7,NOS3,C8orf33,SCRN2 |
| endopeptidase activity | KLK1B24,KLK1B22,ADAMTS3,CTSH,P4HB,PSMA6A,KLK1B4,TPP1,PSMA6B,PSMA8 |
Interacting Protein
PSMA4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PSMA4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PSMA4.
PSMA2;PSMA7;PSMA1;PSMA3
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