PSIP1
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Official Full Name
PC4 and SFRS1 interacting protein 1 -
Overview
The LEDGF (lens epithelium-derived growth factor) gene encodes splice variants P75 and P52 (1). LEDGF (C57G11) Rabbit mAb detects the 75 kDA LEDGF splice form. Both LEDGF variants have transcriptional coactivator functions that may regulate gene transcrip -
Synonyms
PSIP1;PC4 and SFRS1 interacting protein 1;PC4 and SFRS1 interacting protein 2 , PSIP2;PC4 and SFRS1-interacting protein;LEDGF;p52;p75;DFS 70;CLL-associated antigen KW-7;dense fine speckles 70 kDa protein;transcriptional coactivator p52/p75;tran
Recombinant Proteins
- Rat
- Human
- Mouse
- Zebrafish
- Chicken
- E.coli
- Mammalian Cell
- Insect Cell
- Sf9 insect cells
- HEK293
- His
- Non
- His&SUMO
- His&GST
- His&Fc&Avi
Involved Pathway
PSIP1 involved in several pathways and played different roles in them. We selected most pathways PSIP1 participated on our site, such as 2-LTR circle formation,APOBEC3G mediated resistance to HIV-1 infection,Autointegration results in viral DNA circles, which may be useful for your reference. Also, other proteins which involved in the same pathway with PSIP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| HIV Infection | PPIAL4A,AP1S1,CHMP4C,AP1G1,AP1M2,CHMP4B,ELL,TCEB3,PDCD6IP,APOBEC3G |
| Host Interactions of HIV factors | PACS1,DOCK2,PPIAL4A,APOBEC3G,AP1S1,AP1M2,AP1B1,AP1G1,RCC1 |
| Autointegration results in viral DNA circles | BANF1,gag,HMGA1 |
| Early Phase of HIV Life Cycle | gag,BANF1,PPIA,CCR5 |
| HIV Life Cycle | CHMP4C,NMT2,SSRP1,PDCD6IP,RCC1,NMT1,PSTPIP2,TCEB3,CDK9,CHMP4B |
| 2-LTR circle formation | gag,BANF1,HMGA1 |
| Disease | MMAA,TICAM1,RPL35,AP2M1,KREMEN1,CPSF4,TIRAP,AP1M2,OPN1LW,CCR5 |
| APOBEC3G mediated resistance to HIV-1 infection | APOBEC3G,gag,HMGA1,BANF1,PPIA |
Protein Function
PSIP1 has several biochemical functions, for example, RNA polymerase II transcription coactivator activity,activating transcription factor binding,chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PSIP1 itself. We selected most functions PSIP1 had, and list some proteins which have the same functions with PSIP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | PRPF4B,SPATS2,SNRPA,ZCCHC7,NSUN2,DHX35,UTP15,NOP16,DDX50,PRAC |
| RNA polymerase II transcription coactivator activity | CITED1,CITED2,NEUROD1,CITED4,TBX20,NCOA1,TRIM28,TFAP2B,ISL1,RERE |
| protein binding | GPAA1,CARD8,GSK3A,LDHB,FTCD,MID2,RASL11A,ABCG2,GNG4,IQCB1 |
| supercoiled DNA binding | HMGB1,RPS3,HMGB2 |
| chromatin binding | NOC2L,BEND6,C19orf40,HMGN5,NCOA1,TRPS1,TFAP2A,UPF1,HMGB3A,LEF1 |
| activating transcription factor binding | PPARG,TAF9,HDAC7A,EEF1D,DGKQ,MEF2D,MEF2A,SMAD2,PRDM16,EP300 |
Interacting Protein
PSIP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PSIP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PSIP1.
gag-pol
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