PSEN1
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Official Full Name
presenilin 1 -
Overview
Alzheimers disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008] -
Synonyms
PSEN1;presenilin 1;AD3;FAD;PS1;PS-1;S182;presenilin-1
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- Chicken
- Zebrafish
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- His
- Non
- Flag
- DDK
- Myc
- Avi
- Fc
Involved Pathway
PSEN1 involved in several pathways and played different roles in them. We selected most pathways PSEN1 participated on our site, such as Wnt signaling pathway,Notch signaling pathway,Neurotrophin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PSEN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Alzheimers disease | NDUFS5,CASP8,ATP2A3,UQCRB,APOE,CALML3,NOS1,NDUFC2-KCTD14,COX7B2,SDHB |
| Neurotrophin signaling pathway | PIK3CA,ZFP110,MAPK12,IRAK4,MAPK11,TP53,BAD,CALM1,MAP3K5,BCL2 |
| Wnt signaling pathway | DKK4,WNT8A,FZD8B,CUL1B,Fzd4,PPARDB,WNT1,CSNK2A2A,WNT16,PRKCBA |
| Notch signaling pathway | MFAP5,MAML2,RBPJB,KAT2A,NOTCH1,PTCRA,DTX2,DLA,DLC,CNTN6 |
Protein Function
PSEN1 has several biochemical functions, for example, PDZ domain binding,aspartic-type endopeptidase activity,beta-catenin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PSEN1 itself. We selected most functions PSEN1 had, and list some proteins which have the same functions with PSEN1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | PROM1,SPRY1,EFNB1,PLIN3,CDAN1,CNOT10,APEX1,LRRC33,Ar,ATF2 |
| calcium channel activity | PANX1,TRPV6,CACNB2,SLC24A5,TRPC4B,TRPM4,CACNG2A,SLC24A1,CHRNA10,GPM6A |
| endopeptidase activity | AP1S2,PSMB9A,PSMB8F,ACE,P4HB,PSMB5,APH1C,CD46,MMP3,SENP5 |
| cadherin binding | JUP,NEO1,CTNNA2,PTPRM,FXYD5,VCL,NUMB,CD2AP,CTNNA3,AKAP5 |
| aspartic-type endopeptidase activity | Casp3,REN2,PGA4,NRIP2,ANK2B,CTSE,DDI2,CNTNAP5A,PIP,BACE1 |
| beta-catenin binding | Ar,SMAD7,MED12,CHD8,GRIP1,DACT2,LZIC,TCF7L1B,BCL9,SLC9A3R1 |
| PDZ domain binding | PTENA,ACOX1,PLEKHA2,SLC22A5,ARHGAP29,TBC1D10A,KIDINS220,CXXC4,GIPC1,LRP2 |
Interacting Protein
PSEN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PSEN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PSEN1.
APBA1;NCSTN;APP;JUP;PKP4
PSEN1 Related Signal Pathway
Resources
Research Area
Notch PathwayNotch Family
Alzheimer's Disease
E-Cadherin Ectodomain Shedding and Proteolytic Processing
Related Services
Related Products
References
- Reinert, J; Martens, H; et al. A beta(38) in the Brains of Patients with Sporadic and Familial Alzheimer's Disease and Transgenic Mouse Models. JOURNAL OF ALZHEIMERS DISEASE 39:871-881(2014).
- Irwin, DJ; Cohen, TJ; et al. Acetylated Tau Neuropathology in Sporadic and Hereditary Tauopathies. AMERICAN JOURNAL OF PATHOLOGY 183:344-351(2013).
