PRX

  • Official Full Name

    periaxin

  • Overview

    This gene encodes a protein involved in peripheral nerve myelin upkeep. The encoded protein contains 2 PDZ domains which were named after PSD95 (post synaptic density protein), DlgA (Drosophila disc large tumor suppressor), and ZO1 (a mammalian tight junction protein). Two alternatively spliced transcript variants have been described for this gene which encode different protein isoforms and which are targeted differently in the Schwann cell. Mutations in this gene cause Charcot-Marie-Tooth neuoropathy, type 4F and Dejerine-Sottas neuropathy.

  • Synonyms

    PRX;periaxin;KIAA1620;CMT4F

Recombinant Proteins

  • Mouse
  • Rat
  • Human
  • Mammalian Cells
  • HEK293
  • His
  • Myc&DDK
  • His&Fc&Avi

    Involved Pathway

    PRX involved in several pathways and played different roles in them. We selected most pathways PRX participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PRX were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    Protein Function

    PRX has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRX itself. We selected most functions PRX had, and list some proteins which have the same functions with PRX. You can find most of the proteins on our site.

    Function Related Protein
    protein binding RAB26,PICALM,AGRN,AGXT2L2,MSH6,C22orf28,EIF4A3,GTF2IRD2,BLNK,NAA35

    Interacting Protein

    PRX has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRX here. Most of them are supplied by our site. Hope this information will be useful for your research of PRX.

    Ywhae;Kcnma1

    Resources

    References

    • Sangpairoj, K; Changklungmoa, N; et al. Analysis of the expression and antioxidant activity of 2-Cys peroxiredoxin protein in Fasciola gigarttica. EXPERIMENTAL PARASITOLOGY 140:24-32(2014).
    • Meng, FQ; Wang, RX; et al. Genomic organization, single nucleotide polymorphism and functional characterization of natural killer enhancing factor (NKEF-A) in Miichthys miiuy. MOLECULAR BIOLOGY REPORTS 41:651-663(2014).

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