PROZ
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Official Full Name
protein Z, vitamin K-dependent plasma glycoprotein -
Overview
This gene encodes a liver vitamin K-dependent glycoprotein that is synthesized in the liver and secreted into the;plasma. The encoded protein plays a role in regulating blood coagulation by complexing with protein Z-dependent;protease inhibitor to directly inhibit activated factor X at the phospholipid surface. Deficiencies in this protein;are associated with an increased risk of ischemic arterial diseases and fetal loss. Mutations in this gene are the;cause of protein Z deficiency. Alternate splicing results in multiple transcript variants. -
Synonyms
PROZ;protein Z, vitamin K-dependent plasma glycoprotein;vitamin K-dependent protein Z;PZ;Protein Z, vitamin K dependent plasma glycoprotein;OTTHUMP00000018738;OTTHUMP00000018739
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Proz-828M | Recombinant Mouse Proz protein, His & GST-tagged | E.coli | Mouse | His&GST | Ser23~Lys399 |
|
| PROZ-1419HCL | Recombinant Human PROZ cell lysate | Human | Non |
|
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| PROZ-2626H | Recombinant Human PROZ Protein, His-tagged | E.coli | Human | His | Thr282-Asn400 |
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| PROZ-342B | Recombinant Bovine PROZ protein, His&Myc-tagged | E.coli | Bovine | N-His&C-Myc | 47-357aa |
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| PROZ-5470H | Native Human Protein Z, Vitamin K-Dependent Plasma Glycoprotein | Human Plasma | Human | Non |
|
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| PROZ-6673H | Recombinant Human PROZ Protein (Thr282-Asn400), N-GST tagged | E.coli | Human | GST | Thr282-Asn400 |
|
Involved Pathway
PROZ involved in several pathways and played different roles in them. We selected most pathways PROZ participated on our site, such as Gamma carboxylation, hypusine formation and arylsulfatase activation,Gamma-carboxylation of protein precursors,Gamma-carboxylation, transport, and amino-terminal cleavage of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with PROZ were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Gamma-carboxylation, transport, and amino-terminal cleavage of proteins | F9B,GAS6,FURINB,F9A,PROCA,FURINA |
| Post-translational protein modification | EID3,MUC1,STT3A,SPON1B,NAPB,ADAMTS1,PIGK,MCFD2,B3GNT8,TRAPPC9 |
| Gamma-carboxylation of protein precursors | F9A,PROCA,GAS6,F9B |
| Gamma carboxylation, hypusine formation and arylsulfatase activation | FURINB,DPH2,ATPBD4,DPH5,F9A,WDR85,EIF5A2,ARSJ,OTOP2,EEF2 |
| Metabolism of proteins | PFDN1,GFER,LMAN2L,TIMM44,SLC25A13,IGFBP5B,CCT7,TUBA1B,TOMM40,UBA2 |
Protein Function
PROZ has several biochemical functions, for example, calcium ion binding,serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PROZ itself. We selected most functions PROZ had, and list some proteins which have the same functions with PROZ. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| serine-type endopeptidase activity | GM5077,PRSS30,GZMF,F7I,CTRL,PRSS59.2,TMPRSS11D,OVCH2,CLPP,MCPT8 |
| calcium ion binding | S100A1,CANT1A,PCDHA10,PADI1,CAPN8,VIL1,SLIT1B,THBS1,PRF1,JAG1A |
Interacting Protein
PROZ has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PROZ here. Most of them are supplied by our site. Hope this information will be useful for your research of PROZ.
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