PROKR2
-
Official Full Name
prokineticin receptor 2 -
Overview
Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor for prokineticins. The encoded protein is similar in sequence to GPR73, another G protein-coupled receptor for prokineticins. -
Synonyms
PROKR2;prokineticin receptor 2;G protein coupled receptor 73 like 1 , GPR73L1, KAL3, Kallmann syndrome 3 (autosomal dominant);dJ680N4.3;GPR73b;GPRg2;PKR2;PK-R2;G protein-coupled receptor 73-like 1;KAL3;GPR73L1
Recombinant Proteins
- Mouse
- Chicken
- Rat
- Human
- Mus musculus
- Bovine
- Mammalian Cells
- HEK293
- E.coli
- His
- Non
- Avi
- Fc
- DDK
- Myc
Involved Pathway
PROKR2 involved in several pathways and played different roles in them. We selected most pathways PROKR2 participated on our site, such as Class A/1 (Rhodopsin-like receptors),G alpha (q) signalling events,GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with PROKR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| G alpha (q) signalling events | GPR132,FPR-RS6,TRPC7,EDNRB,LPAR1,KALRN,AGTR1,LPAR2A,PROKR1A,CHRM5 |
| Class A/1 (Rhodopsin-like receptors) | NPS,ADRB1,DRD2,ZFPM2B,CCL27,DRD5,TAAR1,EDN2,TAC3,OPN4 |
| Gastrin-CREB signalling pathway via PKC and MAPK | ABHD12,ANXA1A,EDN2,NMU,ANXA1,EDN1,GPR65,ANXA1C,OPN4.1,MLN |
| GPCRs, Other | VMN1R48,GPR132,GPR176,VMN1R41,GPR55,GPR162,GPR77,GPR183,SETD6,V1RA8 |
| GPCR downstream signaling | VIP2,CCR6,ADRA2A,APLNR,CRHR2,CNR1,ADORA2A,RGS6,CRHB,RGS12 |
| GPCR ligand binding | PTH,TAC3,PENKB,ADORA1,ANXA1,XK,TAS2R3,CHRM4,OXER1,GCGB |
| Peptide ligand-binding receptors | NMS,CCBP2,AMCF-II,TRH,CCK,SST,GPR37B,NPB,PYY,CCL27 |
| Signal Transduction | RCA2.1,ACVR1C,MDKB,SOX9B,RHOT1B,PRC1,OPN4,STARD13,OXGR1A.3,GHRB |
Protein Function
PROKR2 has several biochemical functions, for example, G-protein coupled receptor activity,neuropeptide Y receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PROKR2 itself. We selected most functions PROKR2 had, and list some proteins which have the same functions with PROKR2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| G-protein coupled receptor activity | TAS2R120,TAAR13B,OLFR493,TAS2R139,TAAR6,HCAR1-2,OR6Q1,MRGPRA8,LPAR2A,OPN1LW2 |
| neuropeptide Y receptor activity | NPY1R,NPY5R,PRLHR2A,NPY8AR,NPY2R,PROKR1,PRLHR,NPY8BR,QRFPR,PRLH2R |
Interacting Protein
PROKR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PROKR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PROKR2.
Resources
Research Area
FGF FamilyMesenchymal to Epithelial Transition
Neural Stem Cell Markers
Glial Lineage Markers
Related Services
Related Products
References
- Brouillet, S; Hoffmann, P; et al. Molecular Characterization of EG-VEGF-mediated Angiogenesis: Differential Effects on Microvascular and Macrovascular Endothelial Cells. MOLECULAR BIOLOGY OF THE CELL 21:2832-2843(2010).
- Garcia, S; Forteza, J; et al. Matrix metalloproteinase-8 deficiency increases joint inflammation and bone erosion in the K/BxN serum-transfer arthritis model. ARTHRITIS RESEARCH & THERAPY 12:-(2010).
