PPP2R2C
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Official Full Name
protein phosphatase 2, regulatory subunit B, gamma -
Overview
The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. -
Synonyms
PPP2R2C;protein phosphatase 2, regulatory subunit B, gamma;protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), gamma isoform , protein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform;IMYPNO;MGC33570;PP2A subunit B isoform gamma;PR52;PR55G;2ABG_HUMAN;B55 gamma;Gamma isoform of regulatory subunit B55 protein phosphatase 2;IMYPNO 1;IMYPNO1;Phosphoprotein phosphatase 2A BR gamma regulatory chain;PP2A subunit B B gamma isoform;PP2A subunit B B55 gamma isoform;PP2A subunit B isoform B55-gamma;PP2A subunit B isoform PR55-gamma;PP2A subunit B isoform R2-gamma;PP2A subunit B PR55 gamma isoform;PP2A subunit B R2 gamma isoform;PPP2R2C protein;PR 52;PR 55G;Protein phosphatase 2 (formerly 2A) regulatory subunit B gamma isoform;Protein phosphatase 2 regulatory subunit B gamma;Protein phosphatase 2 regulatory subunit B gamma isoform;Protein phosphatase 2A1 B gamma subunit;Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform;Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform;OTTHUMP00000115505;OTTHUMP00000115506;OTTHUMP00000217568;OTTHUMP00000217634;OTTHUMP00000217635;PP2A, subunit B, B-gamma isoform;PP2A, subunit B, R2-gamma isoform;PP2A, subunit B, B55-gamma isoform;PP2A, s;B55-GAMMA
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cell
- Wheat Germ
- Insect Cell
- HEK293
- GST
- His
- Non
- His&Myc
- His&Fc&Avi
Involved Pathway
PPP2R2C involved in several pathways and played different roles in them. We selected most pathways PPP2R2C participated on our site, such as mRNA surveillance pathway,Sphingolipid signaling pathway,PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPP2R2C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Dopaminergic synapse | KIF5A,ATF4,MAOB,GNGT2,MAPK8,GNG12,PPP2R5C,GNAL,PLCB4,PLCB1 |
| Sphingolipid signaling pathway | PDPK1,PIK3R3,FCER1G,PLD1,MAPK1,SPTLC3,PPP2R5E,PPP2R3C,PPP2R5A,DEGS2 |
| mRNA surveillance pathway | PABPC1L2A,PPP2CB,WDR82,RBM8A,NCBP2,NCBP1,NXF2,FIP1L1,PPP2R2CA,SMG6 |
| PIK-Akt signaling pathway | PPP2CA,TCL1B1,IFNAR2,GNG10,PPP2R5D,SPP1,ITGA10,THBS1,LAMA3,PPP2R3A |
| Hippo signaling pathway | WNT2,WNT7B,SMAD2,PARD6B,LEF1,PARD6A,LIMD1,WNT4,CRB1,PPP2R2B |
| Tight junction | CLDNB,CASKB,KRAS,YES1,PRKCE,MAGI1,ACTB1,PRKCDA,CLDN10A,RRAS |
| AMPK signaling pathway | PRKAA1,PFKFB4,PIK3R3,PFKFB3,LIPE,PRKAB1,ACACA,PFKP,AKT3,INS |
| Adrenergic signaling in cardiomyocytes | NETO2,ADRB3B,PRKACBA,CALM4,MAPK3,AKT2,SCN4BA,PLCB1,TMEM8C,TPM4B |
| Hepatitis C | SOS1,MAVS,CLDN17,CD81,IFNA13,PPP2CB,PPP2R2D,CLDN18,IFNA6,IFNA21 |
Protein Function
PPP2R2C has several biochemical functions, for example, protein binding,protein phosphatase type 2A regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPP2R2C itself. We selected most functions PPP2R2C had, and list some proteins which have the same functions with PPP2R2C. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein phosphatase type 2A regulator activity | ARPP19,PPP2R2B,pab1,ENSAA,PPP2R5CB,PPP2R5E,PPP2R2CA,PPP2R5A,IGBP1,PPP2R2BB |
| protein binding | MCC,FTH1,EBF2,PTPLAD1,SLC7A1,EIF4A2,MRPS6,KPNA5,SLC25A18,EEF1G |
Interacting Protein
PPP2R2C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPP2R2C here. Most of them are supplied by our site. Hope this information will be useful for your research of PPP2R2C.
PPP2CA;TCP1;PPP2R1A;CCT6A;CCT5;CCT3;CCT8;CCT4;CCT2;CCT7
PPP2R2C Related Signal Pathway
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