PPP2R2B
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Official Full Name
protein phosphatase 2, regulatory subunit B, beta -
Overview
The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B55 subfamily. Defects in this gene cause autosomal dominant spinocerebellar ataxia 12 (SCA12), a disease caused by degeneration of the cerebellum, sometimes involving the brainstem and spinal cord, and in resulting in poor coordination of speech and body movements. Multiple alternatively spliced variants, which encode different isoforms, have been identified for this gene. The 5 UTR of some of these variants includes a CAG trinucleotide repeat sequence (7-28 copies) that can be expanded to 66-78 copies in cases of SCA12. -
Synonyms
PPP2R2B;protein phosphatase 2, regulatory subunit B, beta;protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform , protein phosphatase 2 (formerly 2A), regulatory subunit B, beta isoform , SCA12, spinocerebellar ataxia 12;serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform;PP2A subunit B isoform beta;PR52B;PR55 BETA;B55 beta;Beta isoform of regulatory subunit B55 protein phosphatase 2;MGC24888;PP2A B55beta;PP2A PR55B;PP2A subunit B B beta isoform;PP2A subunit B B55 beta isoform;PP2A subunit B isoform B55 beta;PP2A subunit B isoform PR55 beta;PP2A subunit B isoform R2 beta;PP2A subunit B PR55 beta isoform;PP2A subunit B R2 beta isoform;PR2AB beta;PR2AB55 beta;PR2APR55 beta;Protein phosphatase 2 (formerly 2A) regulatory subunit B (PR 52) beta isoform;Protein phosphatase 2 (formerly 2A) regulatory subunit B beta isoform;Protein phosphatase 2 regulatory subunit B;Protein phosphatase 2 regulatory subunit B beta isoform;SCA 12;SCA12;Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform;Serine/threonine protein phosphatase 2A neuronal isoform;OTTHUMP00000160097;OTTHUMP00000160098;OTTHUMP00000160099;OTTHUMP00000223707;OTTHUMP00000232496;OTTHUMP00000232497;PP2A subunit B isoform R2-beta;PP2A subunit B isoform B55-be;B55BETA;PR55BETA;PP2ABBETA;PP2APR55B;PR2ABBETA;PR55-BETA;PP2AB55BETA;PR2AB55BETA;PP2APR55BETA;PR2APR55BETA
Recombinant Proteins
- Mouse
- Human
- Rat
- Mammalian Cell
- E.coli
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- GST
- His&Fc&Avi
- N-His&C-Myc
Involved Pathway
PPP2R2B involved in several pathways and played different roles in them. We selected most pathways PPP2R2B participated on our site, such as mRNA surveillance pathway,Sphingolipid signaling pathway,PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPP2R2B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hepatitis C | IFN-a,IFNAR1,LDLR,CLDN10,PPP2R2A,IKBKG,IFNA12,IFNA2,CLDN2,TNFRSF1A |
| mRNA surveillance pathway | MSI2A,PPP2R2C,NCBP1,DAZAP1,FIP1L1,MAGOH2,PABPC1L,PPP2R5EA,CPSF6,SMG7 |
| Hippo signaling pathway | INADL,AREG,BMP4,TCF7,ITGB2,FZD2,GSK3B,WNT2,MPP5,PPP1CA |
| PIK-Akt signaling pathway | EPO,IGF1,IL4R,GNB1,G6PC3,ANGPT1,FGF10,RAF1,IFNB1,ITGA6 |
| Chagas disease (American trypanosomiasis) | PIK3CA,IL6,FADD,GNA15,PIK3R3,TNFRSF1A,CD247,SERPINE1,IRAK1,CD3D |
| Tight junction | GNAI2,PPP2R2BB,MYL5,CLDNJ,MPDZ,MYL9B,SRC,CLDN22,PPP2CA,SMYHC1 |
| Adrenergic signaling in cardiomyocytes | SLC9A1,ATF6B,PPP2R5B,ATP1A2,PLN,PIK3CD,ADRA1B,MAPK11,ATP2B4,ATP2A2 |
| Dopaminergic synapse | ITPR1,CREB3L3,SLC6A3,PPP2CB,CALY,MAPK13,GNG3,CAMK2D,GNG7,CREB3 |
| AMPK signaling pathway | ACACB,ADIPOQ,PPP2CB,PIK3CD,RPS6KB1,G6PC2,CAB39L,PPP2R5C,CD36,AKT1 |
Protein Function
PPP2R2B has several biochemical functions, for example, protein binding,protein phosphatase type 2A regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPP2R2B itself. We selected most functions PPP2R2B had, and list some proteins which have the same functions with PPP2R2B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | PDIA4,SLN,IL1RAPL1,IL4,FTCD,AHCYL1,RIPPLY2,CCDC41,ACLY,KPNA1 |
| protein phosphatase type 2A regulator activity | SET,PPP2R2A,PPP2R4,PPP2R1B,PPP2R3A,PPP2R5B,PPP2R5EB,PPP2R2CA,PPP2R5D,PPP2R5C |
Interacting Protein
PPP2R2B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPP2R2B here. Most of them are supplied by our site. Hope this information will be useful for your research of PPP2R2B.
PPP2R1A;PDPK1;RPS6KB1;a8mq54_human;DDX3X
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References
- Fleming, I; Busse, R; et al. Tyrosine phosphorylation and bradykinin-induced signaling in endothelial cells. AMERICAN JOURNAL OF CARDIOLOGY 80:A102-A109(1997).
- Yang, HX; Jin, GL; et al. Screening and identification of proteins interacting with nucleostemin. WORLD JOURNAL OF GASTROENTEROLOGY 11:4812-4814(2005).
