PPAP2A
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Official Full Name
phosphatidic acid phosphatase type 2A -
Overview
The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is an integral membrane glycoprotein, and has been shown to be a surface enzyme that plays an active role in the hydrolysis and uptake of lipids from extracellular space. The expression of this gene is found to be regulated by androgen in a prostatic adenocarcinoma cell line. At least two alternatively spliced transcript variants encoding distinct isoforms have been described. -
Synonyms
PPAP2A;phosphatidic acid phosphatase type 2A;lipid phosphate phosphohydrolase 1;LPP1;PAP 2a;Lipid phosphate phosphohydrolase 1a;LLP1a;PAP2;PAP2a2;PAP2alpha2;PAPalpha1;Phosphatidic acid phosphatase 2a;Phosphatidic acid phosphohydrolase type 2a;Type 2 phosphatidic acid phosphatase alpha;Type 2 phosphatidic acid phosphohydrolase;PAP2a;PAP2-alpha;phosphatidate phosphohydrolase type 2a;type-2 phosphatidic acid phosphatase alpha;PAP-2a
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PPAP2A-13154M | Recombinant Mouse PPAP2A Protein | Mammalian Cells | Mouse | His |
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| PPAP2A-2992HCL | Recombinant Human PPAP2A 293 Cell Lysate | HEK293 | Human | Non |
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| PPAP2A-6963M | Recombinant Mouse PPAP2A Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| PPAP2A-6963M-B | Recombinant Mouse PPAP2A Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
PPAP2A involved in several pathways and played different roles in them. We selected most pathways PPAP2A participated on our site, such as Glycerolipid metabolism,Glycerophospholipid metabolism,Ether lipid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPAP2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fc gamma R-mediated phagocytosis | FCGR1A,SPHK2,CFL1,PLA2G4F,PIP5K1A,HCK,WASF2,LIMK2,WASF3,FCGR1 |
| Phospholipase D signaling pathway | PTGFR,GRM7,LPAR2,MAPK3,GNAS,AGPAT4,DGKE,TSC1,PIK3CB,MS4A2 |
| Glycerolipid metabolism | ALDH2.2,PNPLA3,LIPC,MOGAT2,MOGAT3A,STIL,MGLL,LPIN2,MBOAT2B,DAK |
| Ether lipid metabolism | PAFAH1B1,PLA2G2A,AGPS,TMEM86B,GAL3ST1A,GAL3ST1,PLA2G4D,ENPP2,CEPT1B,PLA2G6 |
| Choline metabolism in cancer | Pdgfa&Pdgfb,RAF1,MAPK9,SLC44A2,SLC22A3,GRB2,HRAS,RHEB,DGKD,PLA2G4A |
| Sphingolipid metabolism | CERS1,NEU3.1,PPM1L,GBA2,ARSH,GAL3ST1A,ASAH1,DEGS2,SMPD3,GLTPA |
| Metabolic pathways | APRT,PIGL,GNSA,ASL,POLR2E,MAN2A2,HAAO,NDUFA3,NOS2B,ST6GAL1 |
| Glycerophospholipid metabolism | PLA2G1B,PCYT2,PLD3,LCAT,AGPAT4,LPCAT2,CRLS1,PCYT1AA,AGPAT2,ETNPPL |
| Fat digestion and absorption | PLA2G2F,DGAT2,PLA2G12B,ACAT2,MOGAT2,PLA2G2E,SLC27A4,AGPAT1,PLA2G2A,FABP2 |
Protein Function
PPAP2A has several biochemical functions, for example, lipid phosphatase activity,phosphatidate phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPAP2A itself. We selected most functions PPAP2A had, and list some proteins which have the same functions with PPAP2A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| phosphatidate phosphatase activity | PPAPDC1B,LPIN3,LPIN1,PPAP2CB,PPAP2C,LPPR3,LPPR2,PPAPDC1A,PPAP2B,STIL |
| lipid phosphatase activity | PPAP2B,PPAP2CB,PTENB,LPPR1,LPPR5A,INPP5K,LPPR3,PPAP2D,PPAP2C,PTENA |
Interacting Protein
PPAP2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPAP2A here. Most of them are supplied by our site. Hope this information will be useful for your research of PPAP2A.
CREB3;FAHD1;yapB
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