POMP
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Official Full Name
proteasome maturation protein -
Overview
The protein encoded by this gene is a molecular chaperone that binds 20S preproteasome components and is essential for 20S proteasome formation. The 20S proteasome is the proteolytically active component of the 26S proteasome complex. The encoded protein is degraded before the maturation of the 20S proteasome is complete. A variant in the 5 UTR of this gene has been associated with KLICK syndrome, a rare skin disorder. -
Synonyms
POMP;proteasome maturation protein;C13orf12, chromosome 13 open reading frame 12;HSPC014;proteassemblin;UMP1;2510048O06Rik;C13orf12;Chromosome 13 open reading frame 12;HSPC 014;HSPC036 protein;hUMP 1;hUMP1;PNAS 110;PNAS110;Protein UMP1 homolog;UMP 1;Voltage gated K channel beta subunit 4.1;voltage-gated K channel beta subunit 4.1;voltage-gated potassium channel beta subunit 4.1;PNAS-110
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Zebrafish
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
POMP involved in several pathways and played different roles in them. We selected most pathways POMP participated on our site, such as Proteasome, which may be useful for your reference. Also, other proteins which involved in the same pathway with POMP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Proteasome | PSMD11,PSMD11A,PSMA1,PSMA2,PSMC6,PSMB4,PSME4B,PSMC3,PSMC1B,PSMD2 |
Protein Function
POMP has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by POMP itself. We selected most functions POMP had, and list some proteins which have the same functions with POMP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | FBXO4,TES,RRAGA,MRPL51,DIAP1,TP53INP1,SFPI1,SH3BP2,TBC1D20,RALY |
Interacting Protein
POMP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POMP here. Most of them are supplied by our site. Hope this information will be useful for your research of POMP.
PSMB1;PSMB6;PSMB5;PSMB3;PSMB7;PSMA7;E2;KIF1B;KLHL41;PYGM;VCL;CAPN3;GPD1
Resources
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References
- Salinas, J; Caro, MR; et al. High prevalence of antibodies against Chlamydiaceae and Chlamydophila abortus in wild ungulates using two "in house" blocking-ELISA tests. VETERINARY MICROBIOLOGY 135:46-53(2009).
- Fricke, B; Heink, S; et al. The proteasome maturation protein POMP facilitates major steps of 20S proteasome formation at the endoplasmic reticulum. EMBO REPORTS 8:1170-1175(2007).
