POLR2F
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Official Full Name
polymerase (RNA) II (DNA directed) polypeptide F -
Overview
This gene encodes the sixth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes, that is also shared by the other two DNA-directed RNA polymerases. In yeast, this polymerase subunit, in combination with at least two other subunits, forms a structure that stabilizes the transcribing polymerase on the DNA template. -
Synonyms
POLR2F;polymerase (RNA) II (DNA directed) polypeptide F;DNA-directed RNA polymerases I, II, and III subunit RPABC2;DNA directed RNA polymerase II 14.4 kda polypeptide;HRBP14.4;RPB6;DNA directed RNA polymerase II polypeptide F;DNA directed RNA polymerases I, II, and III 14.4 kDa polypeptide;hsRPB6;POLRF;RPABC14.4;RPABC2;RPB14.4;RPC15;RPB6 homolog;OTTHUMP00000199278;OTTHUMP00000199281;RNA Polymerase II subunit 14.4 kD;DNA-directed RNA polymerase II subunit F;RNA polymerases I, II, and III subunit ABC2;DNA direct
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- Chicken
- Zebrafish
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
POLR2F involved in several pathways and played different roles in them. We selected most pathways POLR2F participated on our site, such as Purine metabolism,Pyrimidine metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLR2F were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Epstein-Barr virus infection | HDAC5,PSMC5,HSPB1,HSPA2,ENTPD3,IRF3,PIK3CD,HLA-E,HLA-DQA2,CCNA1 |
| Metabolic pathways | MTHFR,LDHBA,HSD17B10,PFKP,LIPF,HADHB,CKMT2B,PGM1,MIBP,ACAD8 |
| Huntingtons disease | PPARGC1A,TFAM,COX4I1,SDHC,SLC25A6,PPIF,NRF1,NDUFB11,IFT57,NDUFC1 |
| Cytosolic DNA-sensing pathway | IFNA8,PYCARD,IKBKE,CASPA,IFNB,POLR2L,MAVS,IFNA16,CCL4L2,IFNA14 |
| Purine metabolism | POLE4,PNP5B,ENTPD8,POLR2A,PRUNE,NT5C,PRIM2,PFAS,POLR3B,NT5C3L |
| Pyrimidine metabolism | DCK,POLR2GL,CMPK,POLR2H,POLE3,CDA,NME4,POLR2K,TXNRD3,TXNRD2 |
| RNA polymerase | POLR3D,POLR1E,POLR2D,POLR2K,POLR3K,POLR2G,POLR3B,POLR1D,POLR1A,POLR1B |
Protein Function
POLR2F has several biochemical functions, for example, DNA binding,contributes_to RNA polymerase I activity,contributes_to RNA polymerase II activity. Some of the functions are cooperated with other proteins, some of the functions could acted by POLR2F itself. We selected most functions POLR2F had, and list some proteins which have the same functions with POLR2F. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to RNA polymerase II activity | POLR2J,POLR2C,POLR2J3,POLR2K,POLR2L,POLR2B,POLR2J2,POLR2H,POLR2E,POLR2EB |
| contributes_to RNA polymerase III activity | POLR3GLB,POLR2K,POLR3D,POLR3GL,POLR3F,POLR3H,POLR2H,POLR3E,POLR3GLA,POLR1C |
| DNA binding | TRIM28,STAT1B,STRBP,DNAJC2,ZNF134,HOXC9,LIG1,Rhox5,IRX7,ZNF521 |
| contributes_to RNA polymerase I activity | POLR1C,POLR2E,POLR2L,POLR1A,POLR2K,POLR1E,POLR2EB,TWISTNB,POLR1D,POLR2H |
Interacting Protein
POLR2F has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLR2F here. Most of them are supplied by our site. Hope this information will be useful for your research of POLR2F.
MED19;MED26;BDP1;POLR2B;POLR2H;POLR3G;SDC2;IL15RA;GCOM1;MAP3K4;SUPT5H;POLR3A;POLR1C;CD3EAP;MAST3;CRCP;RECQL5
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