POLR1D
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Official Full Name
polymerase (RNA) I polypeptide D, 16kDa -
Overview
The protein encoded by this gene is a component of the RNA polymerase I and RNA polymerase III complexes, which function in the synthesis of ribosomal RNA precursors and small RNAs, respectively. Mutations in this gene are a cause of Treacher Collins syndrome (TCS), a craniofacial development disorder. Alternative splicing results in multiple transcript variants. -
Synonyms
POLR1D;polymerase (RNA) I polypeptide D, 16kDa;DNA-directed RNA polymerases I and III subunit RPAC2;MGC9850;RPA9;RPA16;RPAC2;RPO1 3;FLJ20616;POLR1C;AC19;DNA directed RNA polymerase I 16 kDa polypeptide;DNA directed RNA polymerase I subunit D;DNA directed RNA polymerases I and III subunit RPAC2;DNA-directed RNA polymerase I subunit D;hRPA19;Polymerase (RNA) I polypeptide D;RNA polymerase I 16 kDa subunit;RNA polymerases I and III subunit AC2;RPAC2_HUMAN;RPC16;OTTHUMP00000018172;TCS2;RPO1-3
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Rhesus macaque
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
POLR1D involved in several pathways and played different roles in them. We selected most pathways POLR1D participated on our site, such as Purine metabolism,Pyrimidine metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLR1D were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Epstein-Barr virus infection | PSMC2,HDAC2,MAPK10,RBPJL,RB1,XPO1,IRF3,PIK3R5,TRAF5,HLA-G |
| Metabolic pathways | MDH1AA,NDUFA10,PPAP2A,ME1,CKB,AGPAT3,SPTLC2,ASAH1B,GUK1,MTMR6 |
| RNA polymerase | POLR3GL,POLR3D,POLR2J,POLR2G,POLR1B,POLR2D,POLR2J2,POLR2B,POLR2F,POLR2E |
| Cytosolic DNA-sensing pathway | IFNA13,IFNB1,POLR3C,POLR3E,Ifna15,IFNA17,OSTN,IFNA1,IFNA8,CXCL10 |
| Pyrimidine metabolism | PNP6,PRIM1,PNPT1,POLR3E,NT5C1B,POLR2C,POLR3GL,POLR2GL,UCK2A,POLR2F |
| Purine metabolism | PDE11A,POLR3GLB,NME7,GUCY2E,PNPT1,NT5C3A,ADA,NME6,POLE2,PRPS1 |
Protein Function
POLR1D has several biochemical functions, for example, DNA binding,contributes_to RNA polymerase I activity,contributes_to RNA polymerase III activity. Some of the functions are cooperated with other proteins, some of the functions could acted by POLR1D itself. We selected most functions POLR1D had, and list some proteins which have the same functions with POLR1D. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein dimerization activity | HES2.2,TFAP2C,AHR1A,HEY1,NPAS4,PPP3CA,LMLN,MEF2CA,SIM1B,HER12 |
| contributes_to RNA polymerase I activity | POLR2F,TWISTNB,POLR2H,POLR1C,POLR2E,POLR1E,POLR2EB,POLR2L,POLR2K,ZNRD1 |
| protein binding | TNPO2,KL,SNX1,ZFYVE28,IKBIP,RELL2,MARCKSL1,BBOX1,MAP1LC3B,TJAP1 |
| DNA binding | HMBOX1A,ZNF501,POLR2H,HMGB1B,HIST2H2BB,EP300,E2F2,RXRA,FOXO1A,ABT1 |
| contributes_to RNA polymerase III activity | POLR3E,POLR3GLA,POLR2L,POLR3B,POLR2E,CRCP,POLR3D,POLR3C,POLR2EB,POLR3G |
Interacting Protein
POLR1D has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLR1D here. Most of them are supplied by our site. Hope this information will be useful for your research of POLR1D.
POLR1C;POLR1A;NFKBIB;HAX1;DNAJB6;NR3C1;CDC25A;DDIT3;MAGEA11;CRKL;PXN;MRPL12;GRB2
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References
- Giampietro, PF; Armstrong, L; et al. Whole Exome Sequencing Identifies a POLRID Mutation Segregating in a Father and Two Daughters with Findings of Klippel-Feil and Treacher Collins Syndromes. AMERICAN JOURNAL OF MEDICAL GENETICS PART A 167A:95-102(2015).
- Schaefer, E; Collet, C; et al. Autosomal recessive POLR1D mutation with decrease of TCOF1 mRNA is responsible for Treacher Collins syndrome. GENETICS IN MEDICINE 16:720-724(2014).
