POLDIP3
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Official Full Name
polymerase (DNA-directed), delta interacting protein 3 -
Overview
p70 S6 kinase is a mitogen activated Ser/Thr protein kinase downstream of phosphoinositide-3 kinase (PI3K) and the target of rapamycin, FRAP/mTOR. p70 S6 kinase is required for cell growth and cell cycle progression. SKAR is a recently discovered substrat -
Synonyms
POLDIP3;polymerase (DNA-directed), delta interacting protein 3;polymerase delta-interacting protein 3;KIAA1649;PDIP46;p46;RNA-binding protein P46;S6K1 Aly/REF-like target;polymerase delta interacting protein 46;46 kDa DNA polymerase delta interac
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rhesus macaque
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
POLDIP3 involved in several pathways and played different roles in them. We selected most pathways POLDIP3 participated on our site, such as mTOR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLDIP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| mTOR signaling pathway | EIF4BA,RPS6KA3A,RPS6KA6,RPS6KA3,TSC2,DEPDC6,VEGFAB,INSB,MTOR,EIF4E1C |
Protein Function
POLDIP3 has several biochemical functions, for example, nucleotide binding,poly(A) RNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by POLDIP3 itself. We selected most functions POLDIP3 had, and list some proteins which have the same functions with POLDIP3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | EBNA1BP2,COX4I2,TBCA,PDIA3,PURG,ZCCHC17,U2AF1,RBM14,USP10,FUBP1 |
| protein binding | NUMB,PIK3IP1,KIAA1191,IL36RN,COMTD1,BPTF,ERCC1,SRRT,ATF1,E2F5 |
| nucleotide binding | MAPKAPK2B,RAD51L1,RAVER2,NT5C1B,ABCB4,AGAP2,LRGUK,MYH9A,U2SURP,RBM26 |
Interacting Protein
POLDIP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLDIP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of POLDIP3.
EIF4A3;NCBP1;Erh;USP20;ysuJ;MYH7B;Max;ssrna_cg
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References
- Suzuki, H; Shibagaki, Y; et al. Nuclear TDP-43 causes neuronal toxicity by escaping from the inhibitory regulation by hnRNPs. HUMAN MOLECULAR GENETICS 24:1513-1527(2015).
- Lund, B; Wesolowska-Andersen, A; et al. Host genome variations and risk of infections during induction treatment for childhood acute lymphoblastic leukaemia. EUROPEAN JOURNAL OF HAEMATOLOGY 92:321-330(2014).
