POLD4
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Official Full Name
polymerase (DNA-directed), delta 4 -
Overview
This gene encodes the smallest subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3;to 5 exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein enhances the;activity of DNA polymerase delta and plays a role in fork repair and stabilization through interactions with the DNA;helicase Bloom syndrome protein. Alternatively spliced transcript variants encoding multiple isoforms have been;observed for this gene. -
Synonyms
POLD4;polymerase (DNA-directed), delta 4;DNA polymerase delta subunit 4;DNA polymerase delta smallest subunit p12;p12;POLDS
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- His
- Non
- GST
- His&Fc&Avi
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| POLD4-2282H | Recombinant Human POLD4, His-tagged | E.coli | Human | His | 130aa |
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| POLD4-3505R | Recombinant Rhesus monkey POLD4 Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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| POLD4-3051HCL | Recombinant Human POLD4 293 Cell Lysate | HEK293 | Human | Non |
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| POLD4-301200H | Recombinant Human POLD4 protein, GST-tagged | E.coli | Human | GST | Met1-Leu34 |
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| POLD4-3323R | Recombinant Rhesus Macaque POLD4 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| POLD4-3323R-B | Recombinant Rhesus Macaque POLD4 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| Pold4-4984M | Recombinant Mouse Pold4 Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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| POLD4-5944H | Recombinant Human POLD4 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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Involved Pathway
POLD4 involved in several pathways and played different roles in them. We selected most pathways POLD4 participated on our site, such as Purine metabolism,Pyrimidine metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLD4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | EXTL1,PNMT,CHPF,LCT,COQ2,ATP6V1AA,SRM,POLR3F,GATM,ACOX2 |
| Mismatch repair | RFC5,MLH1,RPA3,MSH6,RFC4,POLD2,EXO1,MLH3,POLD1,PCNA |
| Base excision repair | XRCC1,POLL,NEIL3,APEX2,PARP4,NEIL1,POLD2,POLE3,MPG,TDG |
| Nucleotide Excision Repair | RPA2,COPS4,GTF2H2,GTF2H2C,KIAA1530,GTF2H4,ACTR5,GTF2H1,CCNH,COPS7B |
| Homologous recombination | EME1,RAD54L,POLD1,RPA2,XRCC3,RPA1,RAD51L1,XRCC2,RAD54B,SYCP3 |
| HTLV-I infection | WNT11,PDGFA,HLA-E,MAP3K3,EGR1,AKT2,WNT5A,GM-CSF,TGFBR1,SMAD2 |
| Pyrimidine metabolism | UCKL1,NT5C3A,POLR2H,AK9,CMPK1,PNP6,CMPK2,ITPA,UPB1,POLR1A |
| DNA Replication | GMNN,POLE2,MCM4,RNASEH2A,POLE3,RFC5,POLE4,GINS1,MCM5,GINS4 |
| Purine metabolism | ENTPD8,POLD1,NME3,ADAL,ENTPD2A.1,POLR1C,XDH,NPR2,PDE1A,NT5C1B |
Protein Function
POLD4 has several biochemical functions, for example, DNA-directed DNA polymerase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by POLD4 itself. We selected most functions POLD4 had, and list some proteins which have the same functions with POLD4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ADAM22,HAPLN2,TMEM231,CHD1,PPP3R2,E2F8,CASC3,ANK1,PHB2,NGB |
| DNA-directed DNA polymerase activity | CHRAC1,PRIMPOL,POLD3,POLL,POLG,POLN,POLB,POLG2,POLK,POLE3 |
Interacting Protein
POLD4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLD4 here. Most of them are supplied by our site. Hope this information will be useful for your research of POLD4.
POLD1;POLD2;PCNA;WRNIP1
Resources
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References
- Huang, QM; Suzuki, M; et al. Downregulation of POLD4 in Calu6 cells results in G1-S blockage through suppression of the Akt-Skp2-p27 pathway. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 24:1780-1783(2014).
- Song, HF; Chen, HQ; et al. Genome-wide survey and phylogenetic analysis on subunit sequences of eukaryotic DNA polymerase delta. GENETICS AND MOLECULAR RESEARCH 13:9558-9568(2014).
