POLA1

  • Official Full Name

    polymerase (DNA directed), alpha 1, catalytic subunit

  • Overview

    This gene encodes the catalytic subunit of DNA polymerase, which together with a regulatory and two primase subunits, forms the DNA polymerase alpha complex. The catalytic subunit plays an essential role in the initiation of DNA replication.

  • Synonyms

    POLA1;polymerase (DNA directed), alpha 1, catalytic subunit;POLA, polymerase (DNA directed), alpha , polymerase (DNA directed), alpha 1;DNA polymerase alpha catalytic subunit;p180;DKFZp686K1672;DNA polymerase alpha 1 catalytic subunit;DNA polymerase alpha catalytic subunit p180;DNA polymerase alpha p180 subunit;DPOLA_HUMAN;OTTHUMP00000023089;OTTHUMP00000023090;p180 subunit;POLA;Polymerase (DNA-directed), alpha (70kD)

Recombinant Proteins

  • Human
  • Rat
  • Mouse
  • HeLa
  • E.coli
  • Wheat Germ
  • Mammalian Cells
  • HEK293
  • Non
  • His
  • T7
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
POLA-938H Recombinant Human POLA1 protein HeLa Human Non
POLA1-2944H Recombinant Human POLA1 protein, His-tagged E.coli Human His 1-217 aa
POLA1-28359TH Recombinant Human POLA1 Wheat Germ Human Non 100 amino acids
POLA1-4560R Recombinant Rat POLA1 Protein Mammalian Cells Rat His
POLA1-8020H Recombinant Human POLA1 protein, His & T7-tagged E.coli Human His&T7 Gly1240~Ser1462
Pola1-8021M Recombinant Mouse Pola1 protein, His & T7-tagged E.coli Mouse His&T7 Ala1209~Ser1465
POLA1-4220R Recombinant Rat POLA1 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
POLA1-4220R-B Recombinant Rat POLA1 Protein Pre-coupled Magnetic Beads HEK293 Rat
POLA1-4949H Recombinant Human POLA1 Protein (Gly1240-Ser1462), N-His tagged E.coli Human His Gly1240-Ser1462

    Involved Pathway

    POLA1 involved in several pathways and played different roles in them. We selected most pathways POLA1 participated on our site, such as Purine metabolism,Pyrimidine metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Purine metabolism GUCY1B3,PRUNE,AK7B,ENPP1,GUK1B,ADCY1A,POLE,CANT1B,PNP5B,NME5
    Metabolic pathways ATP5G3B,POLE3,GGT7,ALDH2,DAD1,G6PCA.1,PLCG2,UPRT,HK3,TDO2A
    DNA Replication MCM7,MCM6L,MCM5,RPA4,RNASEH1,POLE4,RFC2,RPA2,RFC4,MCM6
    Pyrimidine metabolism NT5E,POLR2A,PRIM2,TRR1,POLR3K,DPYS,CTPS1A,PNP,POLR2B,DPYDB

    Protein Function

    POLA1 has several biochemical functions, for example, 3-5 exonuclease activity,4 iron, 4 sulfur cluster binding,DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by POLA1 itself. We selected most functions POLA1 had, and list some proteins which have the same functions with POLA1. You can find most of the proteins on our site.

    Function Related Protein
    protein heterodimerization activity MAFGB,PPP2R1A,DMBX1,H2AFVA,PRMT5,CAV1,SUPT5H,HIST1H2AI,BCL2A,BAXA
    nucleoside binding AASS,ACTN4,PNP,CDA
    3-5 exonuclease activity POLE,RAD1,APLF,WRN,POLG,REXO2,REV3L,EXD1,RAD9,APEX1
    protein binding OIP5,ZNF543,KLK15,CYFIP2,ATG4A,NMB,UTF1,CCDC53,CD59,NR0B1
    4 iron, 4 sulfur cluster binding ISCUB,SDHB,ACO2,ETFDH,MOCS1,TYW1,NDUFS2,LIAS,RSAD1,EXO5
    protein kinase binding HDAC4,KIF20A,PTK2,TICAM1,ACVRL1,RPS6,RACGAP1,SPRY2,DNAJA3,SPAG16
    nucleotide binding NME2A,HTATSF1,HNRNPDL,RHOAB,UBE2L3A,EIF4A1B,ABCA5,PRKCBB,RALAA,DNAJC17
    chromatin binding CREB3L1,MLH3,Trl,SMAD2,TRP63,CBFA2T3,ERCC6,CITED2,HMGB2B,NFKB2
    DNA-directed DNA polymerase activity POLD1,PRIMPOL,POLL,POLD3,POLD2,MYBBP1A,POLB,POLE4,POLK,POLA2

    Interacting Protein

    POLA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of POLA1.

    lt_sv40;obp_hhv11;E1;CHM;RPA1;SMC1A;KDM4A;PRIM1

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