PNKP
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Official Full Name
polynucleotide kinase 3-phosphatase -
Overview
This locus represents a gene involved in DNA repair. In response to ionizing radiation or oxidative damage, the protein encoded by this locus catalyzes 5 phosphorylation and 3 dephosphorylation of nucleic acids. Mutations at this locus have been associated with microcephaly, seizures, and developmental delay. -
Synonyms
PNKP;polynucleotide kinase 3-phosphatase;bifunctional polynucleotide phosphatase/kinase;PNK;2(3)-polynucleotidase;DEM 1;DEM1;DNA 5 kinase/3 phosphatase;DNA 5-kinase/3-phosphatase;PNK 1;PNK1;PNKP_HUMAN;Polynucleotide 5 hydroxyl kinase;Polynucleotide 5-hydroxyl-kinase;Polynucleotide kinase 3 prime phosphatase;Polynucleotide kinase 3 phosphatase;Polynucleotide kinase 3-prime-phosphatase;Polynucleotide Kinase;Polynucleotide kinase-3-phosphatase;Homo sapiens polynucleotide kinase 3-phosphatase (PNKP);MCSZ;EIEE10
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PNKP-3964H | Recombinant Human PNKP protein, His-tagged | E.coli | Human | His | 171-521 aa | |
| PNKP-4787Z | Recombinant Zebrafish PNKP | Mammalian Cell | Zebrafish | His |
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| PNKP-1385HCL | Recombinant Human PNKP cell lysate | Human | Non |
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| PNKP-1109H | Recombinant Human PNKP Protein (1-521 aa), His-SUMO-tagged | E.coli | Human | His&SUMO | 1-521 aa |
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| PNKP-2145H | Recombinant Human PNKP Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| Pnkp-4963M | Recombinant Mouse Pnkp Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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Involved Pathway
PNKP involved in several pathways and played different roles in them. We selected most pathways PNKP participated on our site, such as APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway,Base Excision Repair,DNA Repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with PNKP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| DNA Repair | DTL,USP10,TP53BP1,SMARCA5,DDB2,POLD3,RIF1,ACTL6A,COPS3,EYA4 |
| Base excision repair | POLE3,SMUG1,XRCC1,MPG,LIG3,POLB,POLD2,PCNA,TDG.1,NEIL2 |
Protein Function
PNKP has several biochemical functions, for example, ATP binding,ATP-dependent polydeoxyribonucleotide 5-hydroxyl-kinase activity,damaged DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PNKP itself. We selected most functions PNKP had, and list some proteins which have the same functions with PNKP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| polynucleotide 3-phosphatase activity | APTX |
| protein binding | MMP20,C1orf35,AHNAK2,SCRT1,DYRK1A,SLC41A3,PKIA,IPO4,FOXP1,THOC4 |
| ATP binding | ETNK1,STK36,SMC1AL,ATP1A1A.1,MMAB,GSK3AA,RIPK4,DYRK4,CAMKV,IKBKAP |
| ATP-dependent polydeoxyribonucleotide 5-hydroxyl-kinase activity | CLP1 |
| damaged DNA binding | NEIL3,EP300,NEIL2,OGG1,POLH,HMGB2,POLI,TP53BP1,RAD1,UNG |
| double-stranded DNA binding | RAD51L1,TP53,HMGB3,SATB1,MEN1,GTF2H4,SP1,IFI16,XRCC2,MTERFD2 |
| purine nucleotide binding | FAM114A2,P2RX4A |
| endonuclease activity | DNASE2A,SETMAR,EME1,RNASEL3,EAR4,PELO,ZC3H12A,RNASE7,DIS3,OGG1 |
Interacting Protein
PNKP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PNKP here. Most of them are supplied by our site. Hope this information will be useful for your research of PNKP.
XRCC1;XRCC4;ZBTB14
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References
- Gao, R; Liu, YP; et al. Inactivation of PNKP by Mutant ATXN3 Triggers Apoptosis by Activating the DNA Damage-Response Pathway in SCA3. PLOS GENETICS 11:-(2015).
- Chatterjee, A; Saha, S; et al. The Role of the Mammalian DNA End-processing Enzyme Polynucleotide Kinase 3 '-Phosphatase in Spinocerebellar Ataxia Type 3 Pathogenesis. PLOS GENETICS 11:-(2015).
