PMVK
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Official Full Name
phosphomevalonate kinase -
Overview
The enzyme phosphomevalonate kinase (PMVK) catalyzes the conversion of 5-phosphomevalonate into 5-diphosphomevalonate in the cholesterol biosynthetic pathway. PMVK is found in the peroxisome of heart, liver, skeletal muscle, kidney and pancreas tissue wit -
Synonyms
PMVK;phosphomevalonate kinase;HUMPMKI;PMK;PMKA;hPMK;PMKASE
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- DDK
- Myc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PMVK-1812H | Recombinant Human PMVK, GST-tagged | E.coli | Human | GST | 1-192aa | |
| PMVK-2823H | Recombinant Human Phosphomevalonate Kinase, His-tagged | E.coli | Human | His |
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| PMVK-30069TH | Recombinant Human PMVK, His-tagged | E.coli | Human | His | 192 amino acids |
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| PMVK-30070TH | Recombinant Human PMVK, His-tagged | E.coli | Human | His | Full L. 1-192 a.a. |
|
| PMVK-444H | Recombinant Human PMVK, His tagged | E.coli | Human | GST | 1-192 a.a. |
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| PMVK-5431Z | Recombinant Zebrafish PMVK | Mammalian Cells | Zebrafish | His |
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| PMVK-3084HCL | Recombinant Human PMVK 293 Cell Lysate | HEK293 | Human | Non |
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| PMVK-1275H | Recombinant Human PMVK protein, His-tagged | E.coli | Human | His | Met1-Leu192 |
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| Pmvk-4960M | Recombinant Mouse Pmvk Protein, Myc/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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| PMVK-6131H | Recombinant Human PMVK Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | DDK&Myc |
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Involved Pathway
PMVK involved in several pathways and played different roles in them. We selected most pathways PMVK participated on our site, such as Activation of gene expression by SREBF (SREBP),Cholesterol biosynthesis,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PMVK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Regulation of cholesterol biosynthesis by SREBP (SREBF) | MTF1,NFYAL,NFYBB,INSIG2,NFYBA,DHCR7,SREBF2,INSIG1,YY2 |
| Metabolism | DCK,ABHD10,CLPS,MED16,CYP2N13,NDUFA11,DHCR7,BHMT2,ACSM1,NFYBB |
| Activation of gene expression by SREBF (SREBP) | NFYBA,NFYBB,NFYAL,MTF1,DHCR7,CREBBP,CARM1,SREBF2,HELZ2,CYP51A1 |
| Terpenoid backbone biosynthesis | HMGCRA,HMGCR,IDI2,ACAT2,MVDA,HMGCS2,FNTB,IDI1,MVK,ICMT |
| Metabolism of lipids and lipoproteins | INSIG1,CYP2R1,ACOT7,DPEP2,ECI1,MED25,ACAD11,SREBF2,CERS4A,MED6 |
| Metabolic pathways | ALG9,POLE2,DNMT3,UGCG,ANPEPB,HSD3B5,ALOX5A,H6PD,TPH1,TCIRG1 |
| Cholesterol biosynthesis | EBP,DHCR24,ARV1,CYP51A1,LBR,DHCR7,SREBF2 |
| Peroxisome | HAO2,SCP2A,ACAA1A,PXMP2,ABCD3,AGPS,CRATA,ABCD3A,PRDX5,SCP2 |
Protein Function
PMVK has several biochemical functions, for example, ATP binding,phosphomevalonate kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PMVK itself. We selected most functions PMVK had, and list some proteins which have the same functions with PMVK. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | PAK3,EHD1,MAP2K1,OASL,EPHB4B,KIF3CB,TTBK2,OXSR1B,NLK2,MYLK |
Interacting Protein
PMVK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PMVK here. Most of them are supplied by our site. Hope this information will be useful for your research of PMVK.
MPDU1;RGS20;SSB;TBPL1;PITPNA;MLF2;CENPH;q9wmx2-pro_0000037551;VCAM1
Resources
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References
- Rodriguez, SB; Leyh, TS; et al. An Enzymatic Platform for the Synthesis of Isoprenoid Precursors. PLOS ONE 9:-(2014).
- Miziorko, H; VanNice, J; et al. Identification of H. volcanii Phosphomevalonate Decarboxylase and Isopentenyl Phosphate Kinase as Catalysts of the Terminal Enzymatic Reactions in an Archaeal Alternate Mevalonate Pathway. FASEB JOURNAL 28:-(2014).
