PMM2
-
Official Full Name
phosphomannomutase 2 -
Overview
The protein encoded by this gene catalyzes the isomerization of mannose 6-phosphate to mannose 1-phosphate, which is a precursor to GDP-mannose necessary for the synthesis of dolichol-P-oligosaccharides. Mutations in this gene have been shown to cause defects in glycoprotein biosynthesis, which manifests as carbohydrate-deficient glycoprotein syndrome type I. -
Synonyms
PMM2;phosphomannomutase 2;CDG1;CDG1a;CDGS;AI585868;BOS_22465;C86848;CDG 1;MGC127449;PMM 2;OTTHUMP00000160109
Recombinant Proteins
- Zebrafish
- Human
- Chicken
- Rhesus macaque
- Cynomolgus
- Mouse
- Mammalian Cells
- E.coli
- HEK293
- His
- Non
- His&Fc&Avi
- GST
- Myc&DDK
Involved Pathway
PMM2 involved in several pathways and played different roles in them. We selected most pathways PMM2 participated on our site, such as Fructose and mannose metabolism,Amino sugar and nucleotide sugar metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PMM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | IDH3B,GPAA1,IL4I1,APRT,IDUA,DMGDH,ctaG,BCO1L,ARG2,HMBSB |
| Fructose and mannose metabolism | PFKFB2,PFKP,GMPPA,ALDOCA,TPI1A,PFKM,ALDOAB,PFKFB2A,DHRS13L1,HK3 |
| Amino sugar and nucleotide sugar metabolism | CHIA,NANSA,GALK1,GALT,GNPDA2,HK1,AMDHD2,CYB5R2,CHIA.2,PMM1 |
Protein Function
PMM2 has several biochemical functions, for example, phosphomannomutase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PMM2 itself. We selected most functions PMM2 had, and list some proteins which have the same functions with PMM2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| phosphomannomutase activity | PMM1 |
| protein binding | RHOB,FANCF,MBP,FAM50B,ZFP335,ULK1,DPM2,XAB2,ACACA,EDNRB |
Interacting Protein
PMM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PMM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PMM2.
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