PLSCR1
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Official Full Name
Phospholipid Scramblase 1 -
Overview
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. -
Synonyms
Ca(2+)-dependent phospholipid scramblase 1;PL scramblase 1;MMTRA1B;PLSCR1;Erythrocyte phospholipid scramblase;phospholipid scramblase 1;OTTHUMP00000215253;OTTHUMP00000215254;OTTHUMP00000215255;OTTHUMP00000215311;OTTHUMP00000215316
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- E.coli expression system
- GST
- His
- His&T7
- Non
- His&Fc&Avi
Involved Pathway
PLSCR1 involved in several pathways and played different roles in them. We selected most pathways PLSCR1 participated on our site, such as EGFR1 Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLSCR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| EGFR1 Signaling Pathway | ARF4,CEBPB,MTA2,CEACAM1,JUND,DNM1,PTPN12,ABI1B,KLF11,CRKL |
Protein Function
PLSCR1 has several biochemical functions, for example, CD4 receptor binding,DNA binding,SH3 domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PLSCR1 itself. We selected most functions PLSCR1 had, and list some proteins which have the same functions with PLSCR1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | ALS2CR8,FOXD1,JUNB,MYC,EGR1,KLF4,NKX2-8,NPAS4,ZNF750,TCF4 |
| DNA binding | HOXA2B,ZNF45,ZNF12,FOSB,SSBP3A,AHDC1,ARID2,RAG2,TFB1M,ZBTB18 |
| CD4 receptor binding | SPG21,FYN,PLSCR4,LCK |
| epidermal growth factor receptor binding | VAV2,SNX2,EPGN,SHC1,HBEGFB,ATXN2,GRB2,HBEGFA,HBEGF,ARF4 |
| protein binding | DR1,RNF7,USP22,PPP2R5C,DDX55,UHRF2,ERO1LB,IVL,EREG,SEMG1 |
| SH3 domain binding | FMNL3,CIT,KHDRBS2,RAD9,CABYR,GRIK5,CBLC,SH3BP5LA,MYPN,MAPK15 |
| enzyme binding | SNRPD3,GSTM1,CCND1,PEX7,HSPA6,CASC3,ADORA2A,XRCC1,KIAA1967,TSPAN15 |
| phospholipid scramblase activity | ANO4,PLSCR2,PLSCR3A,Ano3,PLSCR3B,PLSCR3,PLSCR4,ANO6,ANO9,ANO7 |
| calcium ion binding | VIL1,CABP5A,PLA2G2A,PPP2R3A,PCDHB16,Npnt,RYR2,PCDH1G2,EDIL3,CRB1 |
Interacting Protein
PLSCR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLSCR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PLSCR1.
GLRX3;EWSR1;DAZAP2;ILF3;polg_hcvco
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References
- Kodigepalli, KM; Nanjundan, M; et al. Induction of PLSCR1 in a STING/IRF3-Dependent Manner upon Vector Transfection in Ovarian Epithelial Cells. PLOS ONE 10:-(2015).
- Yuan, YZ; Tian, CY; et al. Interactome Map Reveals Phospholipid Scramblase 1 as a Novel Regulator of Hepatitis B Virus X Protein. JOURNAL OF PROTEOME RESEARCH 14:154-163(2015).
