PLP1
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Official Full Name
Proteolipid Protein 1 -
Overview
This gene encodes a transmembrane proteolipid protein that is the predominant myelin protein present in the central;nervous system. It may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in;oligodendrocyte development and axonal survival. Mutations in this gene cause X-linked Pelizaeus-Merzbacher disease;and spastic paraplegia type 2. Alternatively spliced transcript variants encoding distinct isoforms or having;different 5 UTRs, have been identified for this gene. -
Synonyms
PLP1;PMD;HLD1;MMPL;SPG2;PLP/DM20;PLP;proteolipid protein 1;myelin proteolipid protein;lipophilin;OTTHUMP00000023761;OTTHUMP00000023762;major myelin proteolipid protein;spastic paraplegia 2, uncomplicated
Recombinant Proteins
- Mouse
- Rhesus macaque
- Rat
- Chicken
- Human
- Taeniopygia guttata (Zebra finch) (Poephila guttata)
- Macaca fascicularis
- Pongo Abelii
- Mus musculus
- Oryctolagus cuniculus (Rabbit)
- Sus scrofa (Pig)
- Bovine
- Dog
- Mammalian Cells
- HEK293
- E.coli
- His
- Non
- His&GST
- His&Fc&Avi
Involved Pathway
PLP1 involved in several pathways and played different roles in them. We selected most pathways PLP1 participated on our site, such as Glial Cell Differentiation,SIDS Susceptibility Pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glial Cell Differentiation | CNP,MBP,GAP43,TPPP |
| SIDS Susceptibility Pathways | KCNJ8,MBD1,MAP2,POU3F2,SP3,CDCA7L,MECP2,TAC1,CREM,POU2F2 |
Protein Function
PLP1 has several biochemical functions, for example, protein binding,structural constituent of myelin sheath,structural molecule activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PLP1 itself. We selected most functions PLP1 had, and list some proteins which have the same functions with PLP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | DNAJC11,NPEPL1,CDKN2AIP,ITGAL,EEA1,KCNIP1,H2-AB1,CXCL14,ABCF1,POLR3GL |
| structural molecule activity | ROCK2,CLDN2,ANK1,MAP7D1,COL15A1B,JUPA,KRT26,ODF2,SPRR2D,CLDN4 |
| structural constituent of myelin sheath | MAL,MBPB,MOBP,NCMAP,MBP |
Interacting Protein
PLP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PLP1.
PTPRN;AKT1;PTPRN;HTT
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References
- Vatter, HA; Di, H; et al. Functional Analyses of the Three Simian Hemorrhagic Fever Virus Nonstructural Protein 1 Papain-Like Proteases. JOURNAL OF VIROLOGY 88:9129-9140(2014).
- Takanashi, J; Nitta, N; et al. Neurochemistry in Shiverer Mouse Depicted on MR Spectroscopy. JOURNAL OF MAGNETIC RESONANCE IMAGING 39:1550-1557(2014).
